NF-kB options are limited

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NF-kB options are limited

机译：NF-kB选项有限

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The transcription factor NF-kB regulates many biological processes and deregulation of the protein contributes to various diseases. Hongbo Hu et al. now show that the deubiquitinase OTUD7B specifically controls one of the major pathways of NF-kB activation - the non-canonical or alternative pathway-by inhibiting proteolysis of TRAF3. OTUD7B deficiency in mice causes severe abnormalities in antibody production and intestinal homeostasis. Because OTUD7B inhibition does not lead to global loss of NF-kB function - the canonical pathway is virtually untouched - this enzyme is a potentially attractive therapeutic target.

机译：转录因子NF-kB调节许多生物过程，而蛋白的失调会导致多种疾病。胡洪波等。现在表明，去泛素化酶OTUD7B通过抑制TRAF3的蛋白水解而特异性地控制NF-kB激活的主要途径之一-非规范或替代途径。小鼠OTUD7B缺乏会导致抗体产生和肠道动态平衡的严重异常。由于OTUD7B的抑制作用不会导致NF-kB功能的整体丧失-规范的途径实际上未被触及-该酶是潜在有吸引力的治疗靶标。

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《Nature》 |2013年第7433期|481-481|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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专利

1. Mitigating greenhouse: Limited time, limited options [J] . Patrick Moriarty, Damon Honnery Energy Policy . 2008,第4期

机译：缓解温室效应：时间有限，选择有限
2. Adding to the debate on the numbers of options for MCQs: the case for not being limited to MCQs with three, four or five options [J] . Mike Tweed BMC Medical Education . 2019,第1期

机译：增加了关于MCQ选项数量的辩论：不限于具有三个，四个或五个选项的MCQ的情况
3. Berberine alleviates oxidative stress in rats with osteoporosis through receptor activator of NF-kB/receptor activator of NF-kB ligand/osteoprotegerin (RANK/RANKL/OPG) pathway [J] . Xiao-Feng He, Long Zhang, Chun-Hua Zhang, Bosnian Journal of Basic Medical Sciences . 2017,第4期

机译：小碱通过NF-kB受体激活剂/ NF-kB配体/骨保护素（RANK / RANKL / OPG）受体激活剂减轻骨质疏松大鼠的氧化应激
4. Options for genetic improvement of Bali cattle -- assessing the strengths and weaknesses of alternative strategies: option 4. basic breeding system with limited selection options [C] . Hans Graser Workshop of the Australian Centre for International Agricultural Research . 2003

机译：巴厘岛遗传改进选项 - 评估替代策略的优势和缺点：选项4.基本育种系统有限选择选项
5. Myeloid specific regulation of NF-KB and M-CSF signaling in HIV-1 and AML. [D] . Kogan, Michael. 2013

机译：HIV-1和AML中NF-KB和M-CSF信号的髓样特异性调节。
6. Adding to the debate on the numbers of options for MCQs: the case for not being limited to MCQs with three four or five options [O] . Mike Tweed 2019

机译：增加了关于MCQ选项数量的辩论：不限于具有三个四个或五个选项的MCQ的情况
7. The cooperation of HMBA with Prostratin to induce recruitment of NF-kB and the function of NF-kB in HIV-1 Nuc1 remodeling [O] . 余冰菲 2012

机译：HMBA与Prostratin的合作诱导NF-kB的募集以及NF-kB在HIV-1 Nuc1重塑中的功能
8. Effects of the NF-kB/Rel Inhibitor IkB-a on NF-kB/Rel on the Pathogenesis of Breast Cancer [R] . Kavanagh, K. , Sonenshein, G. 2000

机译：NF-kB / Rel抑制剂IkB-a对NF-kB /对乳腺癌发病机制的影响

NF-kB options are limited

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