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Cheats never prosper

机译:秘籍永不繁荣

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摘要

Bacterial pathogens promote their survival by deploying virulence factors that modify the host environment. But these virulence proteins are energetically costly to produce, and so avirulent defector mutants that grow more quickly than the wild-type population can compromise the success of an infection. On page 353, Diard et al. report a remarkable strategy used by the gastrointestinal pathogen Salmonella enterica serovar Typhimurium (hereafter termed Salmonella typhimurium) to evade this threat, while at the same time safeguarding its genotype - it produces a subpopulation of equally fast-growing bacteria that are rendered pheno-typically avirulent through regulation of gene expression rather than mutation.
机译:细菌病原体通过部署可改变宿主环境的毒力因子来促进其生存。但是,这些毒力蛋白的生产成本很高,因此,比野生型种群生长速度更快的无毒缺陷突变体会损害感染的成功。在第353页上,Diard等人。报道了胃肠道病原体肠炎沙门氏菌鼠伤寒沙门氏菌(以下简称鼠伤寒沙门氏菌)采用了一种出色的策略来规避这种威胁,同时保护其基因型-它产生了同样快速生长的细菌亚群,这些细菌被赋予表型无毒力。通过调节基因表达而不是突变。

著录项

  • 来源
    《Nature》 |2013年第7437期|321-322|共2页
  • 作者单位

    Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada;

    Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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