The vector as protector

Andrew F. Read; Nicole Mideo

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The vector as protector

机译：载体作为保护剂

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Malaria parasites can kill people, but death is not inevitable. Most infected individuals recover, some after experiencing relatively mild symptoms or none at all. What accounts for this variability? Host factors such as the expression of sickle-cell genes or acquired immunity are part of the explanation. But it is also well known that malaria parasites themselves can be more or less nasty. In this issue, Spence et al. (page 228) report a set of clever experiments in a mouse model of malaria infection that shows that the conditions experienced by parasites before they reach the mammalian bloodstream can determine just how virulent they are.

机译：疟原虫可以杀死人，但死亡并非不可避免。大多数受感染的人可以康复，有些人在经历相对轻微的症状后或根本没有症状。是什么导致这种可变性？镰状细胞基因表达或获得性免疫等宿主因素是解释的一部分。但众所周知，疟原虫本身或多或少会令人讨厌。在本期中，Spence等人。（第228页）报告了在疟疾感染小鼠模型中进行的一系列聪明实验，这些实验表明，寄生虫到达哺乳动物血流之前所经历的条件可以确定它们的毒性。

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来源
《Nature》 |2013年第7453期|177-178|共2页
作者
Andrew F. Read; Nicole Mideo;
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作者单位

the Center for Infectious Disease Dynamics,Departments of Biology and Entomology,Pennsylvania State University, University Park, Pennsylvania 16802, USA;

the Center for Infectious Disease Dynamics,Departments of Biology and Entomology,Pennsylvania State University, University Park, Pennsylvania 16802, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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7. The vector as protector [O] . Andrew F. Read, Nicole Mideo 2013

机译：矢量作为保护者

The vector as protector

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