Ion channel twists to open

Eitan Reuveny

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Ion channel twists to open

机译：离子通道扭曲打开

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摘要

Ion channels are the main units responsible for the electrical activity in our body. They constitute a large family of some 400 proteins in humans. A subfamily of these proteins consists of four GIRK channels, which specialize in converting chemical signals — mostly those of neurotransmitter molecules such as acetyl-choline, dopamine, serotonin and adrenaline — into electrical ones in heart cells and neurons. They are therefore essential for controlling heart rate and the activity of neural circuits. In this issue, Whorton and MacKinnon (page 190) describe the long-awaited crystal structure of the mammalian GIRK2 channel in complex with two subunits of a G protein (a dimer of the Gβ and Gγ subunits), providing information about their mechanism of opening.

机译：离子通道是负责人体体内电活动的主要单位。它们构成了人类约400种蛋白质的大家族。这些蛋白质的一个亚家族由四个GIRK通道组成，这些通道专门用于将化学信号（大部分是神经递质分子，例如乙酰胆碱，多巴胺，5-羟色胺和肾上腺素）转换为心脏细胞和神经元中的电信号。因此，它们对于控制心率和神经回路活动至关重要。在本期杂志中，Whorton和MacKinnon（第190页）描述了期待已久的哺乳动物GIRK2通道的晶体结构，该结构与G蛋白的两个亚基（Gβ和Gγ亚基的二聚体）复合，提供了有关其打开机制的信息。

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来源
《Nature》 |2013年第7453期|182-183|共2页
作者
Eitan Reuveny;
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作者单位

in the Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. Twists and turns in gating ion channels with voltage The EAG potassium channel may use an alternative voltage-dependent gating mechanism [J] . Toombes Gilman E. S., Swartz Kenton J. Science . 2016,第6300期

机译：带有电压的门控离子通道中的曲折曲折EAG钾离子通道可使用其他依赖于电压的门控机制
2. Laminar flow heat transfer enhancement in square and rectangular channels having: (1) A wire-coil, axial and spiral corrugation combined with helical screw-tape with and without oblique teeth and a (2) spiral corrugation combined with twisted tapes with oblique teeth [J] . Emani Madhu Sruthi, Ranjan Hrishiraj, Bharti Anand Kumar, International Journal of Heat and Mass Transfer . 2019,第Deca期

机译：方形和矩形通道中的层流传热增强，其具有：（1）带有斜齿和不带有斜齿的螺旋，螺旋和螺旋线结合的金属丝线圈，轴向和螺旋波纹，以及（2）带有斜齿的扭曲带结合的螺旋波纹
3. Rapid motions of free-surface avalanches down curved and twisted channels and their numerical simulation [J] . Pudasaini SP, Wang YQ, Hutter K Philosophical transactions of the Royal Society. Mathematical, physical, and engineering sciences . 2005,第1832期

机译：自由表面雪崩沿弯曲和扭曲通道的快速运动及其数值模拟
4. EXPERIMENTAL AND NUMERICAL INVESTIGATION OF HEAT TRANSFER IN ANNULAR CHANNELS WITH FLOW TWISTING [C] . S.E. Tarasevich, A.B. Yakovlev, V.L. Fedyaev, ASME summer heat transfer conference . 2012

机译：绕流环形通道传热的实验与数值研究。
5. A theoretical analysis of MIMO processing over copper twisted-pair channels. [D] . Sandstrom, Leif. 2004

机译：铜双绞线信道上MIMO处理的理论分析。
6. Effects of Channel Wall Twisting on the Mixing in a T-Shaped Micro-Channel [O] . Dong Jin Kang 2020

机译：T形微通道中通道壁扭曲对混合的影响
7. Equalization of twisted-pair channels via optimum filtering and noise prediction [O] . R. Cusani, E. Baccarelli, S. Galli 1998

机译：通过最佳滤波和噪声预测均衡双绞线通道

Ion channel twists to open

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