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A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila

机译：味觉受体旁系同源物控制果蝇快速回暖

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摘要

Behavioural responses to temperature are critical for survival, and animals from insects to humans show strong preferences for specific temperatures. Preferred temperature selection promotes avoidance of adverse thermal environments in the short term and maintenance of optimal body temperatures over the long term, but its molecular and cellular basis is largely unknown. Recent studies have generated conflicting views of thermal preference in Drosophila, attributing importance to either internal or peripheral warmth sensors. Here we reconcile these views by showing that thermal preference is not a singular response, but involves multiple systems relevant in different contexts. We found previously that the transient receptor potential channel TRPAI acts internally to control the slowly developing preference response of flies exposed to a shallow thermal gradient. We now find that the rapid response of flies exposed to a steep warmth gradient does not require TRPAI ; rather, the gustatory receptor GR28B(D) drives this behaviour through peripheral thermosensors. Gustatory receptors are a large gene family, widely studied in insect gustation and olfaction, and are implicated in host-seeking by insect disease vectors, but have not previously been implicated in thermosensation. At the molecular level, GR28B(D) misexpression confers thermosensitivity upon diverse cell types, suggesting that it is a warmth sensor. These data reveal a new type of thermosensory molecule and uncover a functional distinction between peripheral and internal warmth sensors in this tiny ectotherm reminiscent of thermoregulatory systems in larger, endothermic animals. The use of multiple, distinct molecules to respond to a given temperature, as observed here, may facilitate independent tuning of an animal's distinct thermosensory responses.
机译：对温度的行为响应对于生存至关重要，并且从昆虫到人类的动物都对特定温度表现出强烈的偏好。优选的温度选择有助于短期内避免不利的热环境，并长期保持最佳体温，但是其分子和细胞基础仍是未知的。最近的研究在果蝇中产生了对热偏好的相互矛盾的观点，这归因于内部或外围温度传感器的重要性。在这里，我们通过显示热偏好不是唯一的响应，而是包含了在不同情况下相关的多个系统来调和这些观点。我们先前发现，瞬时受体电位通道TRPAI在内部起着控制暴露于浅热梯度的果蝇缓慢发展的偏好反应的作用。现在我们发现暴露在陡峭的温暖梯度下的苍蝇的快速反应不需要TRPAI;相反，味觉受体GR28B（D）通过外围热传感器驱动此行为。味觉受体是一个大的基因家族，在昆虫的味觉和嗅觉方面得到了广泛的研究，并且与昆虫疾病载体与寻找宿主有关，但以前并未涉及热敏。在分子水平上，GR28B（D）的错误表达赋予多种细胞类型以热敏性，表明它是一种温暖的传感器。这些数据揭示了一种新型的热敏分子，并在这种微小的等温线中揭示了外围和内部温度传感器之间的功能区别，让人联想到较大的吸热动物的体温调节系统。如此处观察到的，使用多个不同的分子来响应给定的温度可能有助于独立调整动物的不同热感觉响应。

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  • 来源
    《Nature》 |2013年第7464期|580-584|共5页
  • 作者

    Lina Ni; Peter Bronk; Elaine C. Chang; April M. Lowell; Juliette O. Flam; Vincent C. Panzano; Douglas L. Theobald; Leslie C. Griffith; Paul A. Garrity;

  • 作者单位

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

    National Center-for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA,Volen Center for Complex Systems, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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