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Coordination of heart and lung co - development by a multipotent cardiopulmonary progenitor

机译：多能心肺祖细胞协调心脏和肺部的共同发育

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摘要

Co-development of the cardiovascular and pulmonary systems is a recent evolutionary adaption to terrestrial life that couples cardiac output with the gas exchange function of the lung. Here we show that the murine pulmonary vasculature develops even in the absence of lung development. We have identified a population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart that are marked by the expression of Wnt2, Glil and Isll. We show that CPPs arise from cardiac progenitors before lung development. Lineage tracing and clonal analysis demonstrates that CPPs generate the mesoderm lineages within the cardiac inflow tract and lung including cardiomyocytes, pulmonary vascular and airway smooth muscle, proximal vascular endothelium, and pericyte-like cells. CPPs are regulated by hedgehog expression from the foregut endoderm, which is required for connection of the pulmonary vasculature to the heart. Together, these studies identify a novel population of multipotent cardiopulmonary progenitors that coordinates heart and lung co-development that is required for adaptation to terrestrial existence.%心血管和呼吸系统需要精确的共同发育来为血rn液的加氧形成气体交换界面，但心脏和肺是怎rn样一起发育得呢?现在，通过利用一系列小鼠rn模型来进行细胞命运分析和功能丧失分析，rnEdward Mornsey及其同事在心脏的后极内识rn别出一组多能心肺祖细胞，它们协调心脏和肺rn的共同发育。作者提出，心脏和肺已形成了一rn个复杂的、精确的共同发育过程，来确保陆地rn动物在出生后能够存活。
机译：心血管系统和肺系统的共同发展是对陆地生命的最新进化适应，它将心脏输出与肺的气体交换功能耦合在一起。在这里，我们显示即使没有肺发育，鼠的肺血管也会发育。我们已经确定了在心脏后极内以Wnt2，Glil和Isll的表达为标志的多能性心肺中胚层祖细胞（CPP）群体。我们表明，CPPs来自肺祖细胞之前的心脏祖细胞。谱系追踪和克隆分析表明，CPP在心脏流入道和肺内产生中胚层谱系，包括心肌细胞，肺血管和气道平滑肌，近端血管内皮和周细胞样细胞。 CPP受前肠内胚层的刺猬表达调控，这是将肺血管系统连接到心脏所必需的。在一起，这些研究确定了新的多能心肺祖细胞群，它们能协调适应陆地生存所需的心脏和肺部共同发育。％心血管和呼吸系统需要精确的共同发展来为血rn液的加氧形成气体交换界面，但心脏和肺是怎rn样一起发育得呢？现在，通过利用小鼠模型模型进行进行细胞命运分析和功能丧失分析，Edward Mornsey及其同事在心脏的后极内识rn别作者提出，心脏和肺已形成了一堆个个复杂的，精确的共同发育过程，来确保陆地上的动物在出生后能够存活。

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  • 来源
    《Nature》 |2013年第7464期|589-592b1|共5页
  • 作者

    Tien Peng; Ying Tian; Cornells J. Boogerd; Min Min Lu; Rachel S. Kadzik; Kathleen M. Stewart; Sylvia M. Evans; Edward E. Morrisey;

  • 作者单位

    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,Division of Pulmonary and Critical Care, University of Pennsylvania, Philadelphia. Pennsylvania 19104, USA;

    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Medicine, Skaggs School of Pharmacy, University of California, San Diego, San Diego, California 92093, USA;

    Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Cell and Developmental Biology, Perelman School of Medicine atthe University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Medicine, Skaggs School of Pharmacy, University of California, San Diego, San Diego, California 92093, USA;

    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA,Institute for Regenerative Medicine, Philadelphia, Pennyslvania 19104, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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