• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations
【24h】

Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations

机译：四十个不断发展的酵母种群中普遍的遗传搭便车和克隆干扰

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The dynamics of adaptation determine which mutations fix in a population, and hence how reproducible evolution will be. This is central to understanding the spectra of mutations recovered in the evolution of antibiotic resistance, the response of pathogens to immune selection, and the dynamics of cancer progression. In laboratory evolution experiments, demonstrably beneficial mutations are found repeatedly, but are often accompanied by other mutations with no obvious benefit. Here we use whole-genome whole-population sequencing to examine the dynamics of genome sequence evolution at high temporal resolution in 40 replicate Saccharomyces cerevisiae populations growing in rich medium for 1,000 generations. We find pervasive genetic hitchhiking: multiple mutations arise and move synchronously through the population as mutational 'cohorts'. Multiple clonal cohorts are often present simultaneously, competing with each other in the same population. Our results show that patterns of sequence evolution are driven by a balance between these chance effects of hitchhiking and interference, which increase stochastic variation in evolutionary outcomes, and the deterministic action of selection on individual mutations, which favours parallel evolutionary solutions in replicate populations.
机译：适应的动态性决定了哪些突变固定在种群中，因此决定了可重复的进化。这对于理解在抗生素抗性的进化过程中恢复的突变谱，病原体对免疫选择的反应以及癌症进展的动力学至关重要。在实验室进化实验中，反复发现明显有益的突变，但常常伴随着其他突变而没有明显的益处。在这里，我们使用全基因组全种群测序技术，以高时间分辨率检查了在富集培养基中生长了1000代的40个重复酿酒酵母种群中，基因组序列进化的动力学。我们发现普遍的遗传搭便车：出现了多个突变，并作为突变“群体”在人群中同步移动。多个克隆队列通常同时存在，在同一群体中彼此竞争。我们的研究结果表明，序列进化的模式是由搭便车和干扰的机会效应之间的平衡驱动的，这种机会效应增加了进化结果的随机变异性，而选择对个体突变具有决定性作用，这有利于平行种群的平行进化解决方案。

著录项

  • 来源
    《Nature》 |2013年第7464期|571-574|共4页
  • 作者

    Gregory I. Lang; Daniel P. Rice; Mark J. Hickman; Erica Sodergren; George M. Weinstock; David Botstein; Michael M. Desai;

  • 作者单位

    Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA,Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA;

    epartments of Organismicand Evolutionary Biology and of Physics, and FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA;

    epartments of Biological Sciences and Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey 08028, USA;

    The Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA;

    The Genome Institute, Washington University School of Medicine, St. Louis, Missouri 63108, USA;

    Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA;

    epartments of Organismicand Evolutionary Biology and of Physics, and FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号