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Richness of human gut microbiome correlates with metabolic markers

机译：人类肠道微生物组的丰富程度与代谢指标相关

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摘要

肥胖是心血管病、糖尿病、骨质疏松症和包括rn一些癌症在内的其他疾病的一个风险因素。必rn须有其他影响因素存在，才能确定肥胖者会患rn哪种代谢疾病。本期Nature上两篇论文分析这rn些因素中的一个所起作用，这个因素就是肠道rn微生物群的丰富程度。Le Chatelier等人分析了rn非肥胖者和肥胖者的肠道微生物基因组成，发rn现在基因和种类丰富程度上存在显著差别。丰rn富程度较低人士的肥胖程度、胰岛素抗性、血rn脂异常和炎症程度都有所提高。微生物丰富程rn度较低的肥胖者比微生物丰富程度较高者更容rn易增加体重。作者还发现，仅仅对少数几种细rn菌标记进行分析，就足以区分细菌丰富程度的rn高低。Cotillard等人对肥胖或超重人士由饮食rn诱导的体重降低和采用使体重保持稳定的干预rn措施过程中的肠道微生物特征进行了监测。他rn们报告说，高纤维食物(如水果和蔬菜)的消耗rn增加导致细菌丰富程度增加，并且改善一些与rn肥胖相关的临床症状。该发现支持将饮食与肠rn道微生物群的组成联系起来的以前的研究工rn作，并且说明通过适当的饮食也许能实现永久rn性的改变。%We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the popidation) are characterized by more marked overall adiposity, insulin resistance and dysiipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are suMcient to distinguish between individuals with high and low bacteiial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
机译：肥胖是心血管病、糖尿病、骨质疏松症和包括rn一些癌症在内的其他疾病的一个风险因素。必rn须有其他影响因素存在，才能确定肥胖者会患rn哪种代谢疾病。本期Nature上两篇论文分析这rn些因素中的一个所起作用，这个因素就是肠道rn微生物群的丰富程度。 Le Chatelier等人分析了rn非肥胖者和肥胖者的肠道微生物基因组成，发rn现在基因和种类丰富程度上存在显着差别。丰rn富程度较低人士的肥胖程度、胰岛素抗性、血rn脂异常和炎症程度都有所提高。微生物丰富程rn度较低的肥胖者比微生物丰富程度较高者更容rn易增加体重。作者还发现，仅仅对少数几种细rn菌标记进行分析，就足以区分细菌丰富程度的rn高低。 Cotillard等人对肥胖或超重人士由饮食rn诱导的体重降低和采用使体重保持稳定的干预rn措施过程中的肠道微生物特征进行了监测。他rn们报告说，高纤维食物(如水果和蔬菜)的消耗rn增加导致细菌丰富程度增加，并且改善一些与rn肥胖相关的临床症状。该发现支持将饮食与肠rn道微生物群的组成联系起来的以前的研究工rn作，并且说明通过适当的饮食也许能实现永久rn性的改变。 %We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the popidation) are characterized by more marked overall adiposity, insulin resistance and dysiipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are suMcient to distinguish between individuals with high and low bacteiial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets o f individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

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  • 来源
    《Nature》 |2013年第7464期|541-546b1|共7页
  • 作者

    Emmanuelle Le Chatelier; Trine Nielsen; Junjie Qin; Edi Prifti; Falk Hildebrand; et al;

  • 作者单位

    INRA, Institut National de la Recherche Agronomique, US1367 Metagenopolis, 78350 Jouy en Josas, France;

    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark;

    BGI-Shenzhen, Shenzhen 518083, China;

    INRA, Institut National de la Recherche Agronomique, US1367 Metagenopolis, 78350 Jouy en Josas, France;

    Department of Structural Biology, VIB, Pleinlaan 2,1050 Brussels, Belgium,Department of Bioscience Engineering, Vrije Universiteit Brussel, Pleinlaan 2,1050 Brussels, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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