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Mapping the brain's decline

机译:描绘大脑的衰落

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All the memory and cognition tests indicated that the 87-year-old man had Alzheimer's disease, and his brain scan lit up with yellows and reds. The colours were thought to show the presence of tau tangles, the clumps of proteins in the brain that have been linked with Alzheimer's, but the accuracy of the scan had never been verified in humans. So it was filed away. Two weeks later, the man - a participant in a study by Philadelphia, Pennsylvania-based Avid Radiopharmaceuticals - died from an unrelated cause. When his brain was autopsied, researchers found not only amyloid plaques, giving a definitive diagnosis of Alzheimer's disease, but tau tangles in all the same places that lit up in the scan. For the first time, the accuracy of the scan - a form of in-vivo tau imaging - had been confirmed.
机译:所有的记忆和认知测试均表明,这名87岁的男子患有阿尔茨海默氏病,他的大脑扫描点呈黄色和红色。人们认为这些颜色表明存在tau缠结,这是大脑中与阿尔茨海默氏症有关的蛋白质团块,但扫描的准确性从未在人类中得到证实。所以它被归档了。两周后,这名男子-参加了宾夕法尼亚州费城的Avid Radiopharmaceuticals公司的一项研究的参与者-因不相干的原因死亡。当对他的大脑进行尸检时,研究人员不仅发现了淀粉样蛋白斑块,可以对阿尔茨海默氏病做出明确的诊断,而且还发现了在扫描中点亮的所有相同位置的tau缠结。扫描的准确性-体内tau成像的形式-首次被确认。

著录项

  • 来源
    《Nature》 |2013年第7473期|S84-S85|共2页
  • 作者

    SARAH C. P. WILLIAMS;

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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