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A complex problem

机译:一个复杂的问题

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摘要

The immune systems primary task telling friend from foe - is no easy job. Faced with a serious threat such as an infection or wound, the system needs to send defenders out immediately. But it also needs to lie low in the face of innocuous visitors. When confronted by a dangerous outsider, the human body has two lines of defence. There is learned immunity, which is acquired by exposure to a pathogen, either from the environment or through a vaccine. Then there is innate immunity, which is the immediate hard-wired reaction to outside invaders. The key ingredients in the innate response are inflammasomes - large protein complexes that form in response to a perceived threat, sounding the alarm for the body's inflammatory responses.
机译:告诉敌人来自敌人的免疫系统主要任务-绝非易事。面对诸如感染或伤口之类的严重威胁,该系统需要立即将防御者派出。但是面对无害的游客,它也需要低调。面对危险的局外人时,人体有两道防线。学会了免疫力,它是通过暴露于环境或疫苗中的病原体而获得的。然后是先天免疫,这是对外部入侵者的直接硬连线反应。先天性反应的关键成分是炎症小体-响应于感知到的威胁而形成的大蛋白复合物,为人体的炎症反应敲响了警钟。

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  • 来源
    《Nature》 |2013年第7473期|S86-S87|共2页
  • 作者

    KATHARINE GAMMON;

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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