Rough passage across a barrier

BENJAMIN SCHULER; JANE CLARKE

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Rough passage across a barrier

机译：穿越障碍物的艰难通道

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Proteins fluctuate between different conformations to perform their sophisticated tasks. The random motion of water molecules around proteins provides an inexhaustible reservoir of thermal 'kicks', which act as the molecular driving forces of such conformational dynamics. Counterintuitively, the same thermal motions of the solvent also limit the speed of biomolecular motion, an effect known as solvent friction. But it has become increasingly clear that, in some important cases, friction within a protein molecule might be the dominant impediment to its molecular dynamics. In this issue, Chung and Eaton1 (page 685) report one of the most impressive studies so far in which the contribution of such internal friction to dynamics is quantified for protein molecules caught in the act of folding. Remarkably, the results have implications far beyond protein folding.

机译：蛋白质在不同的构象之间波动以执行其复杂的任务。水分子围绕蛋白质的随机运动提供了不竭的热“壁垒”，这些壁垒是这种构象动力学的分子驱动力。与直觉相反，溶剂的相同热运动也限制了生物分子运动的速度，这种作用称为溶剂摩擦。但是，越来越明显的是，在某些重要情况下，蛋白质分子内的摩擦可能是其分子动力学的主要障碍。在本期中，Chung和Eaton1（第685页）报告了迄今为止最令人印象深刻的研究之一，其中定量分析了折叠行为中捕获的蛋白质分子的内摩擦对动力学的贡献。值得注意的是，结果的意义远不止蛋白质折叠。

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来源
《Nature》 |2013年第7473期|632-633|共2页
作者
BENJAMIN SCHULER; JANE CLARKE;
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作者单位

Department of Biochemistry, University of Zurich. 8057 Zurich, Switzerland;

Wellcome Trust Senior Research Fellow in the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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机译：鱼类通过障碍和鱼类通过评估障碍：评估方法和假设对障碍识别和流域连通性量化的影响
2. Barriers to fish passage and barriers to fish passage assessments: the impact of assessment methods and assumptions on barrier identification and quantification of watershed connectivity [J] . Christina M. Bourne, Dan G. Kehler, Yolanda F. Wiersma, Aquatic Ecology . 2011,第3期

机译：鱼类通过障碍和鱼类通过评估障碍：评估方法和假设对障碍识别和流域连通性量化的影响
3. Rough passage [J] . JOSE G. RIERA AOPA pilot . 2019,第8期

机译：粗糙的通道
4. Should Fish Passage through Culverts be a Concern for Midwest Engineers and Planners: Determining the Percentage of Culverts that act as Barriers to Fish Passage in NE Ohio [C] . Rayamajhi B, Vasconcelos JG, Devkota JP, World environmental and water resources congress . 2012

机译：中西部的工程师和计划者是否应该关注通过涵洞的鱼通过：确定在俄亥俄州东北部作为鱼通过障碍的涵洞的百分比
5. Reunited at Last: Genetic Recovery of Stream Fish Populations after Removal of Passage Barriers [D] . Prasko, Lauren M. 2019

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6. Account of a Case of Trismatic Tetanus Produced by the Passage of Large Rough and Angular Pieces of Clay from the Intestinal Canal into the Vagina and Cured by Tobacco Injections [O] . Burleigh Smart 1831

机译：一例三头破伤风的病例由大粗糙和角状粘土从肠管进入阴道而产生并经烟草注射治疗
7. Barriers to fish passage and barriers to fish passage assessments: the udimpact of assessment methods and assumptions on barrier identification and udquantification of watershed connectivity [O] . Wiersma Yolanda 2011

机译：鱼类通过的障碍和鱼类通过评估的障碍： ud评估方法和假设对屏障识别的影响和 ud流域连通性的量化
8. Experimental and theoretical studies of friction and heat transfer in rough passages. Progress report, August 1-November 30, 1990. [R] . Obot, N. T., Esen, E. B. 1990

机译：粗糙通道中摩擦和传热的实验和理论研究。进展报告，1990年8月1日至11月30日。

Rough passage across a barrier

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