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Where we are now with Alzheimer's

机译:阿尔茨海默氏症患者现在在哪里

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摘要

In the Mini Mental State Examination, a questionnaire used worldwide to evaluate the severity of dementia, an early question is "Where are we now?" That is also the primary question of Margaret Lock's The Alzheimer Conundrum. This anthropological study peers back at a century of grappling with Alzheimer's disease (AD) and surveys the quest to understand its mechanisms and the scientific enterprise needed to unravel them. Lock dares to pose big questions, and is well prepared to do so. For ten years, she intensively studied epidemiological and neurobio-logical research on AD, went to meetings, and interviewed experts, people at risk and carers. The result reads like a travel diary, with a balance between engagement and objectivity. Lock highlights how scientific progress can be both accelerated and impeded by paradigms, the entangled interests of the pharmaceutical industry, the media and personal beliefs. She covers the history of AD, prominent views on its cause, risk factors such as mild cognitive impairment, and biomarkers.
机译:在全球范围内用于评估痴呆严重程度的问卷“迷你精神状态检查”中,一个早期的问题是“我们现在在哪里?”这也是玛格丽特·洛克的《阿尔茨海默氏症》的主要问题。这项人类学研究回顾了一个世纪以来与阿尔茨海默氏病(AD)的角力,并进行了调查以了解其机制以及阐明其机制所需的科学知识。洛克敢于提出大问题,并已做好充分准备。十年来,她对AD的流行病学和神经生物学研究进行了深入研究,参加了会议,并采访了专家,高危人群和护理人员。结果读起来就像旅行日记,在参与度和客观性之间保持平衡。洛克强调了范式,制药业纠结的利益,媒体和个人信仰如何既可以加速又可以阻碍科学进步。她介绍了AD的历史,其病因的重要观点,轻度认知障碍等危险因素以及生物标志物。

著录项

  • 来源
    《Nature》 |2013年第7474期|38-38|共1页
  • 作者

    Eus Van Someren;

  • 作者单位

    Sleep & Cognition department of the Netherlands Institute for Neuroscience of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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