• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Interactions between cancer stem cells and their niche govern metastatic colonization
【24h】

Interactions between cancer stem cells and their niche govern metastatic colonization

机译：癌症干细胞与其生态位之间的相互作用决定着转移定植

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps1. Although dissemination of tumour cells seems to be an early and frequent event2, the successful initiation of metastatic growth, a process termed 'metastatic colonization', is inefficient for many cancer types and is accomplished only by a minority of cancer cells that reach distant sites3'4. Prevalent target sites are characteristic of many tumour entities5, suggesting that inadequate support by distant tissues contributes to the inefficiency of the metastatic process. Here we show that a small population of cancer stem cells is critical for metastatic colonization, that is, the initial expansion of cancer cells at the secondary site, and that stromal niche signals are crucial to this expansion process. We find that periostin (POSTN), a component of the extracellular matrix, is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour. Infiltrating tumour cells need to induce stromal POSTN expression in the secondary target organ (in this case lung) to initiate colonization. POSTN is required to allow cancer stem cell maintenance, and blocking its function prevents metastasis. POSTN recruits Wnt ligands and thereby increases Wnt signalling in cancer stem cells. We suggest that the education of stromal cells by infiltrating tumour cells is an important step in metastatic colonization and that preventing de novo niche formation may be a novel strategy for the treatment of metastatic disease.
机译：远处器官的转移性生长是癌症死亡的主要原因。转移的发展是一个多阶段的过程，具有多个限速步骤1。尽管扩散肿瘤细胞似乎是一个早期且频繁的事件2，但转移性生长的成功启动（一个称为“转移性定殖”的过程）对于许多类型的癌症而言效率低下，并且只能通过少数到达远处的癌细胞来实现[3]。 4。常见的靶位点是许多肿瘤实体的特征5，表明远处组织的支持不足会导致转移过程效率低下。在这里，我们显示了少量的癌症干细胞对于转移性定殖至关重要，也就是说，癌细胞在第二个位点的初始扩增，而基质位利基信号对于该扩增过程至关重要。我们发现骨膜素（POSTN），细胞外基质的一个组成部分，在正常组织和原发性肿瘤的基质中由成纤维细胞表达。浸润的肿瘤细胞需要在次要靶器官（在这种情况下为肺）中诱导基质POSTN表达，以开始定植。需要POSTN才能维护癌症干细胞，阻断POSTN的功能可以防止转移。 POSTN募集Wnt配体，从而增加癌症干细胞中的Wnt信号传导。我们建议，通过浸润肿瘤细胞对基质细胞进行培养是转移定殖的重要步骤，而预防从头生态位的形成可能是治疗转移性疾病的新策略。

著录项

  • 来源
    《Nature》 |2012年第7379期|p.85-89|共5页
  • 作者

    Ilaria Malanchi; Albert Santamaria-Martinez; Evelyn Susanto; Hong Peng; Hans-Anton Lehr; Jean-Francois Delaloye; Joerg Huelsken;

  • 作者单位

    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research 'Molecular Oncology', 1015 Lausanne, Switzerland;

    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research 'Molecular Oncology', 1015 Lausanne, Switzerland;

    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research 'Molecular Oncology', 1015 Lausanne, Switzerland;

    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research 'Molecular Oncology', 1015 Lausanne, Switzerland,Nanfang Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Southern Medical University, Guangzhou 510515, China;

    University Institute of Pathology, CHUV, University of Lausanne,1011 Lausanne, Switzerland;

    Department of Gynecology and Obstetrics, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland;

    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research 'Molecular Oncology', 1015 Lausanne, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号