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The right neighbour

机译:正确的邻居

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摘要

Coping with a lifetime of tissue function, injury and disease requires replenishment of the cells that make up organs. Replacement cells originate from adult-tissue stem cells such as haematopoietic stem cells, which continually form all types of blood cell. The growth and activity of tissue stem cells is regulated by neighbouring cells that comprise the stem-cell niche — a microenvironment containing regulatory signalling molecules. Identifying, controlling and mimicking the niche signals represent challenges for the emerging field of regenerative medicine. On page 457 of this issue, Ding et al.~1 identify the cells that produce a signal called stem-cell factor, which is essential for the generation of new blood cells from haematopoietic stem cells in embryonic and adult mice.
机译:为了应对一生的组织功能,损伤和疾病,需要补充组成器官的细胞。替代细胞起源于成年组织干细胞,例如造血干细胞,它们不断形成所有类型的血细胞。组织干细胞的生长和活性由构成干细胞小生境的邻近细胞调节,该细胞是一种含有调控信号分子的微环境。识别,控制和模仿利基信号代表了新兴的再生医学领域的挑战。在此问题的第457页上,Ding等人〜1确定了产生信号的细胞,称为干细胞因子,这对于从胚胎和成年小鼠的造血干细胞中产生新的血细胞至关重要。

著录项

  • 来源
    《Nature》 |2012年第7382期|p.453-455|共3页
  • 作者单位

    Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts 02115, USA;

    Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts 02115, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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