Tumour initiation modelled

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Tumour initiation modelled

机译：肿瘤起始模型

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How a mutant cell in otherwise normal tissue escapes its tightly regulated environment to become cancerous is still not clear. In a three-dimensional cell-culture model of mammary epithelial tissue, Cheuk Leung and Joan Brugge have been able to mimic the very first stages of tumorigenesis. They introduce oncogenes into single cells and show that genes, such as ERBB2, that promote translocation of targeted cells into the lumen by perturbing local matrix adhesion can also drive clonal outgrowth, if the cells are capable of anchorage-independent survival.

机译：尚不清楚正常组织中的突变细胞如何逃脱其严格调节的环境而变成癌性。在乳腺上皮组织的三维细胞培养模型中，Cheuk Leung和Joan Brugge能够模仿肿瘤发生的最初阶段。他们将致癌基因引入单细胞，并表明通过扰动局部基质粘附来促进靶细胞向内腔转运的基因（如ERBB2）也可以驱动克隆生长，如果这些细胞能够独立于锚定存活。

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《Nature》 |2012年第7384期|p.163|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Response to letter from Dr Oliviera in relation to our publication: A study in a rat initiation-promotion bladder tumour model demonstrated no promoter/progressor potential of dapagliflozin [J] . Billger Martin, Kirk Jason, Chang Jane, Regulatory Toxicology and Pharmacology: RTP . 2019,第期

机译：回应来自Oliviera博士与我们的出版物相关的信：大鼠启动促进膀胱肿瘤模型中的研究证明了Dapagliflozin的启动子/进展潜力
2. Re: A study in a rat initiation-promotion bladder tumour model demonstrated no promoter/progressor potential of dapagliflozin [J] . Oliveira P. A., Seixas F. Regulatory Toxicology and Pharmacology: RTP . 2019,第期

机译：Re：在大鼠启动 - 促进膀胱肿瘤模型中的研究证明了Dapagliflozin的启动子/进化潜力
3. A study in a rat initiation-promotion bladder tumour model demonstrated no promoter/progressor potential of dapagliflozin [J] . Billger Martin, Kirk Jason, Chang Jane, Regulatory Toxicology and Pharmacology: RTP . 2019,第期

机译：大鼠启动促进膀胱肿瘤模型的研究证明了Dapagliflozin的启动子/进化潜力
4. Development of Breast and Tumour Models for Simulation of Novel Multimodal PEM-UWB Technique for Detection and Classification of Breast Tumours [C] . Raquel C. Conceicao, Martin OHalloran, Ricardo M. Capote, IEEE Nuclear Science Symposium and Medical Imaging Conference . 2012

机译：乳腺癌模拟乳腺癌模型，用于乳腺肿瘤检测和分类的新型多媒体PEM-UWB技术
5. The Role of Parathyroid Hormone-Related Protein (PTHrP) in Tumour Initiation, Promotion and Metastasis of Breast Cancer. [D] . Li, Jiarong. 2010

机译：甲状旁腺激素相关蛋白（PTHrP）在乳腺癌的肿瘤发生，促进和转移中的作用。
6. Mathematical Modelling of a Brain Tumour Initiation and Early Development: A Coupled Model of Glioblastoma Growth Pre-Existing Vessel Co-Option Angiogenesis and Blood Perfusion [O] . Yan Cai, Jie Wu, Zhiyong Li, -1

机译：脑肿瘤启动和早期发育的数学模型：胶质母细胞瘤生长预先存在的血管共选项血管生成和血液灌注的耦合模型。
7. Mathematical Modelling of a Brain Tumour Initiation and Early Development: A Coupled Model of Glioblastoma Growth, Pre-Existing Vessel Co-Option, Angiogenesis and Blood Perfusion. [O] . Yan Cai, Jie Wu, Zhiyong Li, 2016

机译：脑肿瘤起始和早期发育的数学模型：胶质母细胞瘤生长，既往血管共同选择，血管生成和血液灌注的耦合模型。

Tumour initiation modelled

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