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The Drosophila melanogaster Genetic Reference Panel

机译：果蝇果蝇遗传参考小组

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摘要

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.
机译：生物学的主要挑战是了解分子遗传变异与数量性状变异（包括适应性）之间的关系。这种关系决定了我们从基因型预测表型以及了解进化力如何塑造物种内部和物种之间变异的能力。先前的解剖基因型-表型图的努力是基于不完整的基因型信息。在这里，我们描述了果蝇果蝇遗传参考小组（DGRP），这是一种用于分析种群基因组学和数量性状的社区资源。 DGRP由来源于自然种群的全序列自交系组成。群体基因组分析表明，着丝粒常染色体区域和X染色体的多态性降低，正负选择的证据以及X染色体的快速进化。新基因中的许多变异（大多数是低频的）与定量性状相关，并解释了大部分表型变异。 DGRP利用果蝇遗传学的功能促进基因型-表型作图。

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  • 来源
    《Nature》 |2012年第7384期|p.173-178|共6页
  • 作者

    Trudy F. C. Mackay; Stephen Richards; Eric A. Stone; Antonio Barbadilla; Julien F. Ayroles; et al;

  • 作者单位

    Department ot Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA;

    Human Genome Sequencing Center, Baylor College ot Medicine, One Baylor Plaza, Houston, Texas 77030 USA;

    Department ot Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA;

    Genomics, Bioinformatics and Evolution Group, Institut de Biotecnologia i de Biomedicina - IBB/Department of Genetics and Microbiology, Campus Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain;

    Department ot Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA,FAS Society of Fellows, Harvard University, 78 Mt Auburn Street, Cambridge, Massachusetts 02138, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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