Blocking tumour sugar metabolism

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Blocking tumour sugar metabolism

机译：阻断肿瘤糖代谢

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An emerging strategy in cancer drug development is to target key metabolic molecules in tumours. Researchers have pinpointed one for prostate cancer: an enzyme involved in glucose metabolism that seems to be crucial to cancer survival. Almut Schulze at the Cancer Research UK London Research Institute and her colleagues found that the survival of three different prostate cancer cell lines depended on glucose.

机译：癌症药物开发中的一种新兴策略是靶向肿瘤中的关键代谢分子。研究人员已经确定了一种用于前列腺癌的酶：一种参与葡萄糖代谢的酶，似乎对癌症的生存至关重要。英国伦敦癌症研究所的阿尔穆特·舒尔兹（Almut Schulze）及其同事发现，三种不同的前列腺癌细胞系的存活取决于葡萄糖。

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《Nature》 |2012年第7391期|p.512|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Blocking hexose entry into glycolysis activates alternative metabolic conversion of these sugars and upregulates pentose metabolism in Aspergillus nidulans [J] . Claire Khosravi, Evy Battaglia, Roland S. Kun, BMC Genomics . 2018,第1期

机译：阻止己糖进入糖酵解会激活这些糖的替代代谢转化，并上调构巢曲霉中的戊糖代谢
2. Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth [J] . J B Patel, J Mehta, A Belosay, British Journal of Cancer . 2007,第8期

机译：新型维甲酸代谢阻断剂对人乳腺癌细胞和肿瘤生长具有有效的抑制作用
3. Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice [J] . C K Huynh, A M H Brodie, V C O Njar British Journal of Cancer . 2006,第4期

机译：视黄酸代谢阻断剂（RAMBAs）对SCID小鼠中人前列腺癌细胞和LNCaP前列腺肿瘤异种移植物的生长的抑制作用
4. TRACER: a 3D engineered tumour for mapping cell metabolism and phenotype in heterogeneous microenvironments [C] . Darren Rodenhizer, Edoardo Gaude, Dan Cojocari, World biomaterials congress . 2016

机译：TRACER：3D工程化肿瘤，可绘制异质微环境中的细胞代谢和表型
5. Novel Insights Into Sugar and Succinate Metabolism of Actinobacillus succinogenes from Strains Evolved for Improved Growth on Lignocellulose Hydrolysate Sugars. [D] . McPherson, Nikolas Robin. 2017

机译：对菌株的琥珀酸放线杆菌的糖和琥珀酸代谢的新见解不断发展，以改善木质纤维素水解糖的生长。
6. Blocking hexose entry into glycolysis activates alternative metabolic conversion of these sugars and upregulates pentose metabolism in Aspergillus nidulans [O] . Claire Khosravi, Evy Battaglia, Roland S. Kun, 2018

机译：阻止己糖进入糖酵解会激活这些糖的替代代谢转化并上调构巢曲霉中的戊糖代谢
7. Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth [O] . Patel, J B, Mehta, J, Belosay, A, 2007

机译：新型维甲酸代谢阻断剂对人乳腺癌细胞和肿瘤生长具有有效的抑制作用

Blocking tumour sugar metabolism

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