Possible anti-diabetes target

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Possible anti-diabetes target

机译：可能的抗糖尿病目标

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Glut4, the major insulin responsive glucose transporter, is downregulated in adipose tissue in obesity and type 2 diabetes. Mark Herman et al. now show that GLUT4-mediated glucose uptake induces expression of ChREBP, which regulates the expression of lipogenic and glycolytic genes.

机译：Glut4是主要的胰岛素反应性葡萄糖转运蛋白，在肥胖和2型糖尿病的脂肪组织中被下调。马克·赫曼（Mark Herman）等。现在表明，GLUT4介导的葡萄糖摄取诱导ChREBP的表达，从而调节脂肪形成和糖酵解基因的表达。

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《Nature》 |2012年第7392期|p.39|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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专利

1. Target recognition and network pharmacology for revealing anti-diabetes mechanisms of natural product [J] . Wang Ying, Hu Baichun, Feng Shasha, Journal of computational science . 2020,第Sepa期

机译：揭示天然产物抗糖尿病机制的目标识别与网络药理学
2. Autophagy as a target for development of anti-diabetes drugs derived from natural compounds [J] . Zhang Xiao-Wei, Zhou Ji-Chao, Hu Zhuo-Wei Journal of Asian natural products research . 2017,第3a4期

机译：自噬作为衍生自天然化合物的抗糖尿病药物的目标
3. Simultaneous determination of anti-diabetes/anti-obesity drugs by LC/PDA, and targeted analysis of sibutramine analog in dietary supplements by LC/MS/MS. [J] . Kim SH, Lee J, Yoon T Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2009,第12期

机译：通过LC / PDA同时测定抗糖尿病/抗肥胖药，并通过LC / MS / MS进行膳食补充剂中西布曲明类似物的靶向分析。
4. Molecular docking simulation of mangostin derivatives and curcuminoid on maltase- glucoamylase target for searching anti-diabetes drug candidates [C] . T Sumaryada, Arwansyah, A W Roslia, International Conference on Biomedical Engineering . 2016

机译：芒果衍生物和姜黄素与麦芽糖酶-葡糖淀粉酶靶标的分子对接模拟，用于寻找抗糖尿病药物
5. The effects of target ethnicity, target gender, and target income on individuals' perceptions of multiple category target groups [D] . Glover, Crystal Michelle 2008

机译：目标种族，目标性别和目标收入对个人对多个类别目标群体的看法的影响
6. New insights into the links between anti-diabetes drugs and gut microbiota [O] . Ruixin Hu, Yanting Yuan, Chaolong Liu, 2021

机译：新见解抗糖尿病药物和肠道微生物的联系
7. PDB21 A Systematic review and network meta-analysis of anti-Diabetes Treatments for adults with type 2 Diabetes Mellitus Inadequately Controlled on Insulin and Oral anti-Diabetes Drugs [O] . Orme M., Mukherjee J., Sternhufvud C., 2015

机译：PDB21对胰岛素和口服抗糖尿病药物控制不充分的2型糖尿病成年人的抗糖尿病治疗的系统评价和网络荟萃分析
8. Targeting: The Joint Targeting Process and Procedures for Targeting Time-Critical Targets. [R] . 1997

机译：定位：针对时间关键目标的联合定位流程和程序。

Possible anti-diabetes target

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