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Unexpected features of Drosophila circadian behavioural rhythms under natural conditions

机译：果蝇在自然条件下昼夜节律行为节律的异常特征。

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摘要

我们目前对生物节律的认识很多都依赖于施加rn在实验室中的动物身上的明一暗周期。现在，rnCharalarrlbos Kyriacou及其同事对户外半封闭rn环境中的果蝇的节律行为进行了监测。他们发rn现了很多与实验室中研究工作的显著差别，如rn在据信控制昼夜节律的基因上发生了突变的果rn蝇中存在野生型表现型。本文作者们还发现了“节律性带动”(rhlytrlmic entrainment)的不同rn来源(包括温度和月光)之间的新的平衡。这些rn发现表明，我们需要对一些被广泛接受的概念rn进行一次全面的重新审视，这些概念如生物钟rn和昼夜预测以及它们在野生环境中实际上所具rn有的适应性价值等。%Circadian clocks have evolved to synchronize physiology, metabolism and behaviour to the 24-h geophysical cycles of the Earth1. Drosophila melanogastei's rhythmic locomotor behaviour provides the main phenotype for the identification of higher eukar-yotic clock genes2'3. Under laboratory light-dark cycles, flies show enhanced activity before lights on and off signals4'5, and these anticipatory responses have defined the neuronal sites of the corresponding morning (M) and evening (E) oscillators67. However, the natural environment provides much richer cycling environmental stimuli than the laboratory, so we sought to examine fly locomotor rhythms in the wild. Here we show that several key laboratory-based assumptions about circadian behaviour are not supported by natural observations. These include the anticipation of light transitions, the midday 'siesta', the fly's crepuscular activity, its nocturnal behaviour under moonlight, and the dominance of light stimuli over temperature. We also observe a third major locomotor component in addition to M and E, which we term 'A' (afternoon). Furthermore, we show that these natural rhythm phe-notypes can be observed in the laboratory by using realistic temperature and light cycle simulations. Our results suggest that a comprehensive re-examination of circadian behaviour and its molecular readouts under simulated natural conditions will provide a more authentic interpretation of the adaptive significance of this important rhythmic phenotype. Such studies should also help to clarify the underlying molecular and neuroanatomical substrates of the clock under natural protocols.
机译：我们目前对生物节律的认识很多都依赖于施加rn在实验室中的动物身上的明一暗周期。现在，rnCharalarrlbos Kyriacou及其同事对户外半封闭rn环境中的果蝇的节律行为进行了监测。他们发rn现了很多与实验室中研究工作的显着差别，如rn在据信控制昼夜节律的基因上发生了突变的果rn蝇中存在野生型表现型。本文作者们还发现了“节律性带动”(rhlytrlmic entrainment)的不同rn来源(包括温度和月光)之间的新的平衡。这些rn发现表明，我们需要对一些被广泛接受的概念rn进行一次全面的重新审视，这些概念如生物钟rn和昼夜预测以及它们在野生环境中实际上所具rn有的适应性价值等。 %Circadian clocks have evolved to synchronize physiology, metabolism and behaviour to the 24-h geophysical cycles of the Earth1. Drosophila melanogastei's rhythmic locomotor behaviour provides the main phenotype for the identification of higher eukar-yotic clock genes2'3. Under laboratory light-dark cycles, flies show enhanced activity before lights on and off signals4'5, and these anticipatory responses have defined the neuronal sites of the corresponding morning (M) and evening (E) oscillators67. However, the natural environment provides much richer cycling environmental stimuli than the laboratory, so we sought to examine fly locomotor rhythms in the wild. Here we show that several key laboratory-based assumptions about circadian behaviour are not supported by natural observations. These include the anticipation of light transitions, the midday 'siesta', the fly's crepuscular activity, its nocturnal behaviour under moonlight, and the dominance of light stimuli over temperature. We a lso observe a third major locomotor component in addition to M and E, which we term 'A' (afternoon). Furthermore, we show that these natural rhythm phe-notypes can be observed in the laboratory by using realistic temperature and light cycle simulations. Our results suggest that a comprehensive re-examination of circadian behaviour and its molecular readouts under simulated natural conditions will provide a more authentic interpretation of the adaptive significance of this important rhythmic phenotype. Such studies should also help to clarify the underlying molecular and neuroanatomical substrates of the clock under natural protocols.

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  • 来源
    《Nature》 |2012年第7394期|p.371-375C3C5|共7页
  • 作者

    Stefano Vanin; Supriya Bhutani; Stefano Montelli; Pamela Menegazzi; Edward W. Green; Mirko Pegoraro; Federica Sandrelli; Rodolfo Costa; Charalambos P. Kyriacou;

  • 作者单位

    Department of Biology, University of Padova, Padova 35131, Italy;

    Department of Genetics, University of Leicester, LEI 7RH, UK;

    Department of Biology, University of Padova, Padova 35131, Italy.;

    Department of Biology, University of Padova, Padova 35131, Italy;

    Department of Genetics, University of Leicester, LEI 7RH, UK;

    Department of Biology, University of Padova, Padova 35131, Italy;

    Department of Biology, University of Padova, Padova 35131, Italy;

    Department of Biology, University of Padova, Padova 35131, Italy;

    Department of Genetics, University of Leicester, LEI 7RH, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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