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Local generation of glia is a major astrocyte source in postnatal cortex

机译：胶质细胞的局部生成是产后皮质中星形胶质细胞的主要来源

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摘要

Glial cells constitute nearly 50% of the cells in the human brain1. Astrocytes, which make up the largest glial population, are crucial to the regulation of synaptic connectivity during postnatal development2. Because defects in astrocyte generation are associated with severe neurological disorders such as brain tumours3, it is important to understand how astrocytes are produced. Astrocytes reportedly arise from two sources4"6: radial glia in the ventricular zone and progenitors in the subventricular zone, with the contribution from each region shifting with time. During the first three weeks of postnatal development, the glial cell population, which contains predominantly astrocytes, expands 6-8-fold in the rodent brain7. Little is known about the mechanisms underlying this expansion. Here we show that a major source of glia in the postnatal cortex in mice is the local proliferation of differentiated astrocytes. Unlike glial progenitors in the subventricular zone, differentiated astrocytes undergo symmetric division, and their progeny integrate functionally into the existing glial network as mature astrocytes that form endfeet with blood vessels, couple electrically to neighbouring astrocytes, and take up glutamate after neuronal activity.
机译：胶质细胞占人脑中细胞的近50％1。星形胶质细胞是最大的神经胶质细胞群，对产后发育过程中突触连接的调节至关重要。由于星形胶质细胞生成的缺陷与严重的神经系统疾病（如脑瘤）有关，因此了解星形胶质细胞是如何产生的很重要。星形胶质细胞据报道来自两个来源4“ 6：心室区的放射状胶质细胞和脑室下区的祖细胞，每个区域的贡献均随时间而变化。在出生后的前三周，神经胶质细胞群主要包含星形胶质细胞。 ，在啮齿动物的大脑中扩展6-8倍7.关于这种扩展的机制鲜为人知。在这里，我们显示了小鼠出生后皮层中神经胶质的主要来源是分化的星形胶质细胞的局部增殖。脑室下区域，分化的星形胶质细胞进行对称分裂，它们的后代功能性整合到现有的神经胶质网络中，成为成熟的星形胶质细胞，与血管形成末端，与邻近的星形胶质细胞电耦合，并在神经元活动后吸收谷氨酸。

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  • 来源
    《Nature》 |2012年第7394期|p.376-380|共5页
  • 作者

    Woo-Ping Ge; Atsushi Miyawaki; Fred H. Gage; Yuh Nung Jan; Lily Yeh Jan;

  • 作者单位

    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California at San Francisco, 1550 4th Street, San Francisco, California 94158, USA;

    Life Functionand Dynamics, Exploratory Research for Advanced Technoiogy, Japan Science and Technology Agency, and Brain Science Institute, RIKEN, Wako-city, Saitama, 351-0198, Japan;

    Laboratory of Genetics,The Salk Institute for Biological Studies, La Jolla, California 92037, USA;

    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California at San Francisco, 1550 4th Street, San Francisco, California 94158, USA;

    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry and Biophysics, University of California at San Francisco, 1550 4th Street, San Francisco, California 94158, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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