DNA replication caught in the act

KENNETH A.JOHNSON

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DNA replication caught in the act

机译：DNA复制陷入困境

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During the first half of the twentieth century, biochemists pondered the identity of genetic material with great wonderment. How can biological material replicate itself? This question was answered, in principle, when James Watson and Francis Crick proposed that DNA had a double-helical structure1, which seemed to suggest that each of the two strands could serve as a template for self-replication using specific base-pairing rules. However, the structural and energetic differences between the canonical Watson-Crick base pairs and mismatched base pairs are so subtle that one is left wondering how cellular machinery can catalyse DNA replication with sufficient speed and accuracy to sustain life.

机译：在二十世纪上半叶，生物化学家们对遗传物质的身份深表怀疑。生物材料如何自我复制？原则上，当詹姆斯·沃森和弗朗西斯·克里克提出DNA具有双螺旋结构时，这一问题得到了回答1，这似乎表明两条链中的每条都可以用作使用特定碱基配对规则进行自我复制的模板。然而，规范的沃森-克里克碱基对和错配碱基对之间在结构和能量上的差异是如此微妙，以至于人们一直想知道细胞机制如何以足够的速度和精度催化DNA复制以维持生命。

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《Nature》 |2012年第7406期|p.177-178|共2页
作者
KENNETH A.JOHNSON;
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作者单位

Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Texas 78735, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. The kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress The kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress The kinase domain residue serine 173 of Schizosaccharomyces pombe Chk1 kinase is critical for the response to DNA replication stress [J] . Naomi Coulton, Thomas Caspari Biology Open . 2017,第12期

机译：粟酒裂殖酵母Chk1激酶的激酶结构域残基丝氨酸173对DNA复制压力的响应至关重要粟酒裂殖酵母Chk1的激酶结构域残基丝氨酸173对DNA复制应激的反应至关重要。激酶对于DNA复制压力的反应至关重要
2. DNA DamageDNA damage and DNA Replication StressDNA replication stress in Yeast Models of Aging. [J] . William C Burhans, Martin Weinberger Sub-cellular biochemistry . 2012,第Null期

机译：DNA损伤DNA损伤和DNA复制应力酵母老化模型中的DNA复制应力。
3. DNA REPLICATION MACHINERY - FUNCTIONAL CHARACTERIZATION OF A COMPLEX CONTAINING DNA POLYMERASE ALPHA, DNA POLYMERASE DELTA, AND REPLICATION FACTOR C SUGGESTS AN ASYMMETRIC DNA POLYMERASE DIMER [J] . Maga G, Hubscher U Biochemistry . 1996,第18期

机译：DNA复制机器-包含DNA聚合酶α，DNA聚合酶δ和复制因子C的复合物的功能表征建议不对称的DNA聚合酶二聚体
4. HDX/MS of the E. coli replicative DNA polymerase identifies stabilizing interactions between the DNA sliding clamp, exonuclease and clamp loader [C] . Rafael Fernandez Leiro, Sarah L. Maslen, Meindert H. Lamers, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：大肠杆菌复制DNA聚合酶的HDX / MS识别DNA滑动夹，外切核酸酶和夹具装载机之间的稳定相互作用
5. A group of homologous DNA replication origins and replicators dispersed throughout the human genome & Anticancer compounds targeting DNA replication initiation proteins from Chinese medicinal herbals. [D] . Wang, Ziyi. 2010

机译：一组同源的DNA复制起点和复制子，分布在整个人类基因组中，并且具有针对中草药DNA复制起始蛋白的抗癌化合物。
6. SARS-CoV-2 Does Not Replicate in Aedes Mosquito Cells nor Present in Field-Caught Mosquitoes from Wuhan [O] . Han Xia, Evans Atoni, Lu Zhao, 2020

机译：SARS-CoV-2不会在武汉野外捕获的蚊子中不存在的伊蚊中复制
7. Mutations That Decrease DNA Binding of the Processivity Factor of the Herpes Simplex Virus DNA Polymerase Reduce Viral Yield, Alter the Kinetics of Viral DNA Replication, and Decrease the Fidelity of DNA Replication▿ [O] . Jiang, Changying, Hwang, Ying T., Randell, John C. W., 2007

机译：减少单纯疱疹病毒DNA聚合酶持续性因子的DNA结合的突变会降低病毒产量，改变病毒DNA复制的动力学并降低DNA复制的保真度▿

DNA replication caught in the act

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