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A subset of dopamine neurons signals reward for odour memory in Drosophila

机译：多巴胺神经元的一个子集表示果蝇气味记忆的奖励

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摘要

Animals approach stimuli that predict a pleasant outcome. After the paired presentation of an odour and a reward, Drosophila melanogaster can develop a conditioned approach towards that odour. Despite recent advances in understanding the neural circuits for associative memory and appetitive motivation, the cellular mechanisms for reward processing in the fly brain are unknown. Here we show that a group of dopamine neurons in the protocerebral anterior medial (PAM) cluster signals sugar reward by transient activation and inactivation of target neurons in intact behaving flies. These dopamine neurons are selectively required for the reinforcing property of, but not a reflexive response to, the sugar stimulus. In vivo calcium imaging revealed that these neurons are activated by sugar ingestion and the activation is increased on starvation. The output sites of the PAM neurons are mainly localized to the medial lobes of the mushroom bodies (MBs), where appetitive olfactory associative memory is formed. We therefore propose that the PAM cluster neurons endow a positive predictive value to the odour in the MBs. Dopamine in insects is known to mediate aversive reinforcement signals. Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs.
机译：动物接近可以预料到令人愉快的结果的刺激。将气味和奖励配对呈现后，果蝇可以开发出一种针对该气味的有条件方法。尽管最近在理解用于联想记忆和食欲动机的神经回路方面取得了进步，但是在飞行大脑中进行奖励处理的细胞机制尚不清楚。在这里，我们显示在前脑前内侧（PAM）簇中的一组多巴胺神经元通过完好无损的行为正常的目标神经元的瞬时激活和失活来发出糖奖励信号。这些多巴胺神经元是糖刺激的增强特性而非反射反应的选择性需要。体内钙成像显示，这些神经元被糖摄入激活，饥饿时激活增加。 PAM神经元的输出位点主要定位在蘑菇体（MBs）的内侧叶，在此处形成食欲性嗅觉联想记忆。因此，我们建议PAM簇神经元赋予MBs中的气味正预测值。已知昆虫中的多巴胺会介导厌恶性增强信号。我们的结果强调了多巴胺的各种作用背后的细胞特异性以及MBs中空间隔离的局部回路的重要性。

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  • 来源
    《Nature》 |2012年第7412期|p.512-516|共5页
  • 作者

    Chang Liu; Pierre-Yves Plagais; Nobuhiro Yamagata; Barret D. Pfeiffer; Yoshinori Aso; Anja B. Friedrich; Igor Siwanowicz; Gerald M. Rubin; Thomas Preat; Hiromu Tanimoto;

  • 作者单位

    Max-Planck-lnstitut fuer Neurobiologie, Martinsried 82152, Germany,Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, China,Graduate University of the Chinese Academy of Sciences, Beijing 100049, China;

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Centre National de la Recherche Scientifique, Ecole Superieure de Physique et de Chimie Industrielles, 75005 Paris, France;

    Max-Planck-lnstitut fuer Neurobiologie, Martinsried 82152, Germany;

    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

    Max-Planck-lnstitut fuer Neurobiologie, Martinsried 82152, Germany,Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

    Max-Planck-lnstitut fuer Neurobiologie, Martinsried 82152, Germany;

    Max-Planck-lnstitut fuer Neurobiologie, Martinsried 82152, Germany;

    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA;

    Genes and Dynamics of Memory Systems, Neurobiology Unit, Centre National de la Recherche Scientifique, Ecole Superieure de Physique et de Chimie Industrielles, 75005 Paris, France;

    Max-Planck-lnstitut fuer Neurobiologie, Martinsried 82152, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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