Mitochondrial gene replacement

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Mitochondrial gene replacement

机译：线粒体基因替代

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Mutations in mitochondrial DNA (mtDNA) cause various human diseases. Inheritance is from the mother because all zygotic mitochondria come from the oocyte. Shoukhrat Mitalipov and colleagues previously reported proof-of-concept replacement of mtDNA through chromosome spindle transfer in macaque oocytes. They now extend the technology to human ooycytes. They also report on the health of a three-year old macaque born from an mtDNA-replaced oocyte. This work suggests that replacement therapy for mtDNA disorders could become a reality.

机译：线粒体DNA（mtDNA）的突变会导致各种人类疾病。遗传来自母亲，因为所有合子线粒体均来自卵母细胞。 Shoukhrat Mitalipov及其同事先前报道了通过猕猴卵母细胞中染色体纺锤体转移对mtDNA进行概念验证。他们现在将技术扩展到人类卵细胞。他们还报告了由mtDNA取代的卵母细胞出生的三岁猕猴的健康状况。这项工作表明，mtDNA疾病的替代治疗可能成为现实。

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《Nature》 |2012年第7421期|p.489|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA [J] . Paine, Ananta Frontiers in Cellular Neuroscience . 2016,第2016期

机译：预防和治疗线粒体DNA有害突变引起的遗传性神经退行性疾病的线粒体置换术的承诺和陷阱
2. Discovery of the rpl10 gene in diverse plant mitochondrial genomes and its probable replacement by the nuclear gene for chloroplast RPL10 in two lineages of angiosperms. [J] . Kubo N, Arimura S DNA research: an international journal for rapid publication of reports on genes and genomes . 2010,第1期

机译：在多种植物线粒体基因组中发现rpl10基因，并可能被两个被子植物谱系中的叶绿体RPL10的核基因取代。
3. Discovery of the rpl10 Gene in Diverse Plant Mitochondrial Genomes and Its Probable Replacement by the Nuclear Gene for Chloroplast RPL10 in Two Lineages of Angiosperms [J] . Nakao Kubo, Shin-ichi Arimura DNA research: an international journal for rapid publication of reports on genes and genomes . 2010,第1期

机译：在两个植物被子植物线粒体基因组中发现rpl10基因，并可能被叶绿体RPL10的核基因取代。
4. Enhanced Generation of Mitochondrial Reactive Oxygen Species in Cybrids Containing 4977-bp Mitochondrial DNA Deletion [C] . MEI-JIE JOU, TSUNG-I PENG, HONG-YUEH WU, Asian Society for Mitochondrial Research and Medicine . 2005

机译：增强含有4977-BP线粒体DNA缺失的糖线电池活性氧物质的产生
5. Evolution in light of mitonuclear landscapes: An examination of mitochondrial replacement in killifish (Fundulus spp.). [D] . Flanagan, Stephen David. 2016

机译：根据微核景观进行的进化：鳞纹鱼类的线粒体置换研究（Fundulus spp。）。
6. Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA [O] . Ananta Paine, Manoj Kumar Jaiswal 2016

机译：预防和治疗线粒体DNA有害突变导致的遗传性神经退行性疾病的线粒体置换术的承诺和陷阱
7. Mitochondrial Replacement Therapy: Modifying Genes to Prevent Inherited Mitochondrial Disease [O] . Jennifer Kramer 2019

机译：线粒体替代疗法：改性基因以防止遗传性线粒体疾病
8. SIRT3 is a Mitochondrial Tumor Suppressor and Genetic Loss Results in a Murine Model for ER/PR-Positive Mammary Tumors Connecting Metabolism and Carcinogenesis Mitochondrial Tumor Suppressor. Revision [R] . Freeman, M 2013

机译：sIRT3是线粒体肿瘤抑制因子和遗传损失导致小鼠模型的ER / pR阳性乳腺肿瘤连接代谢和致癌线粒体肿瘤抑制因子。调整

Mitochondrial gene replacement

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