CXCR1 structure in a membrane

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CXCR1 structure in a membrane

机译：膜中的CXCR1结构

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G-protein coupled receptors (GPCRs) are ubiquitous membrane proteins that transduce chemical signals from the outside of a cell, and many of them are drug targets. Sang Ho Park et al. now present a new nuclear magnetic resonance spectroscopy method for the study of membrane proteins in phospholipid bilayers and use it to determine the structure of human CXCR1, a high-affinity GPCR for interleukin-8, a major mediator of immune and inflammatory responses.

机译：G蛋白偶联受体（GPCR）是一种普遍存在的膜蛋白，可从细胞外部传导化学信号，其中许多是药物靶标。 Sang Ho Park等。现在，我们提出了一种新的核磁共振波谱方法，用于研究磷脂双层中的膜蛋白，并将其用于确定人CXCR1的结构，这是一种针对白细胞介素8的高亲和力GPCR，白细胞介素8是免疫和炎症反应的主要介体。

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《Nature》 |2012年第7421期|p.489|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Membrane-induced organization and dynamics of the N-terminal domain of chemokine receptor CXCR1: insights from atomistic simulations [J] . Kharche Shalmali, Joshi Manali, Sengupta Durba, Chemistry and Physics of Lipids . 2018,第期

机译：趋化因子受体CXCR1的N-末端结构域的膜诱导的组织和动力学：原子模拟的见解
2. Characterization and expression of the CXCR1 and CXCR4 in miiuy croaker and evolutionary analysis shows the strong positive selection pressures imposed in mammal CXCR1 [J] . Tianjun Xu, Zhihuang Zhu, Yuena Sun, Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology . 2014,第1期

机译：CXCR1和CXCR4在小鱼中的表征和表达以及进化分析表明，哺乳动物CXCR1具有强的正选择压力
3. Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy [J] . Berkamp Sabrina, Park Sang Ho, De Angelis Anna A., Journal of Biomolecular NMR . 2017,第3期

机译：单体白细胞介素-8的结构及其与溶液NMR光谱法与CXCR1的N-末端结合位点I的相互作用
4. Inflammation and Clearance of Streptococcus uberis Significantly Tied to Genetic Variation in CXCR1 Amino Acid Expression [C] . Gina M Pighetti, Susan Headrick, Mark Lewis, Annual Meeting of the National^Mastitis^Council . 2013

机译：链球菌Uberis的炎症和清除显着涉及CXCR1氨基酸表达的遗传变异
5. Solid-State Nuclear Magnetic Resonance Studies of the Structures, Membrane Locations, Cholesterol Contact, and Membrane Motions of Membrane-Associated HIV Fusion Peptide (HFP). [D] . Jia, Lihui. 2017

机译：固态核磁共振研究的结构，膜位置，胆固醇接触和膜相关的HIV融合肽（HFP）的膜运动。
6. Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy [O] . Sabrina Berkamp, Sang Ho Park, Anna A. De Angelis, -1

机译：溶液NMR光谱分析单体白介素8的结构及其与CXCR1 N末端结合位点I的相互作用
7. Membrane interaction of the N-terminal domain of chemokine receptor CXCR1 [O] . Haldar Sourav, Raghuraman H., Namani Trishool, 2010

机译：趋化因子受体CXCR1 N末端结构域的膜相互作用

CXCR1 structure in a membrane

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