• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Identification of a rudimentary neural crest in a non-vertebrate chordate
【24h】

Identification of a rudimentary neural crest in a non-vertebrate chordate

机译：鉴定非脊椎酸盐中最基本的神经c

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

使脊椎动物与其他动物如此不同的很多特点都rn与头有关，其中包括头盖骨和专门化的眼睛及rn耳朵。头的形式在很大程度上是由神经嵴(神rn经冠)细胞决定的，这些细胞源自胚胎中被称rn为“神经板”的、形成中枢神经系统的区域，rn然后在整个身体中迁移，帮助形成各种不同组rn织。神经嵴的起源一直是一个谜。这项研究显rn示，作为脊椎动物的一个远亲，独居海鞘有一rn个源自“神经板”边缘的细胞系。这些细胞表rn达几个神经嵴分化基因，但却没有神经嵴的某rn些明确特性(如长距离迁移)。然而，调控基因rn。Twist的定向“误表达”就足以诱导这些特性中rn的其中一些。这些结果表明，神经嵴基因网络rn大部分是在被囊动物和脊椎动物分化前出现rn的，“间叶细胞”决定因子(如Twist)向“神经rn板”外胚层中的“共择”，对于脊椎动物“新rn头”的出现极为关键。封面图片-由NickrnHobgood在东帝汶近岸拍摄的一组独居“蓝色rn响铃”被囊动物(Clavelina moluccensis)。%Neural crest arises at the neural plate border, expresses a core set of regulatory genes and produces a diverse array of cell types, including ectomesenchyme derivatives that elaborate the vertebrate head. The evolution of neural crest has been proposed to be a key event leading to the appearance of new cell types that fostered the transition from filter feeding to active predation in ancestral vertebrates. However, the origin of neural crest remains controversial, as homologous cell types have not been unambiguously identified in non-vertebrate chordates. Here we show that the tunicate Ciona intestinalis possesses a cephalic melanocyte lineage (a9.49) similar to neural crest that can be reprogrammed into migrating 'ectomesenchyme' by the targeted misexpression of Twist (also known as twist-like 2). Our results suggest that the neural crest melanocyte regulatory network pre-dated the divergence of tunicates and vertebrates. We propose that the co-option of mesenchyme determinants, such as Twist, into the neural plate ectoderm was crucial to the emergence of the vertebrate 'new head'.
机译：使脊椎动物与其他动物如此不同的很多特点都rn与头有关，其中包括头盖骨和专门化的眼睛及rn耳朵。头的形式在很大程度上是由神经嵴(神rn经冠)细胞决定的，这些细胞源自胚胎中被称rn为“神经板”的、形成中枢神经系统的区域，rn然后在整个身体中迁移，帮助形成各种不同组rn织。神经嵴的起源一直是一个谜。这项研究显rn示，作为脊椎动物的一个远亲，独居海鞘有一rn个源自“神经板”边缘的细胞系。这些细胞表rn达几个神经嵴分化基因，但却没有神经嵴的某rn些明确特性(如长距离迁移)。然而，调控基因rn。Twist的定向“误表达”就足以诱导这些特性中rn的其中一些。这些结果表明，神经嵴基因网络rn大部分是在被囊动物和脊椎动物分化前出现rn的，“间叶细胞”决定因子(如Twist)向“神经rn板”外胚层中的“共择”，对于脊椎动物“新rn头”的出现极为关键。封面图片-由NickrnHobgood在东帝汶近岸拍摄的一组独居“蓝色rn响铃”被囊动物(Clavelina moluccensis)。%Neural crest arises at the neural plate border, expresses a core set of regulatory genes and produces a diverse array of cell types, including ectomesenchyme derivatives that elaborate the vertebrate head. The evolution of neural crest has been proposed to be a key event leading to the appearance of new cell types that fostered the transition from filter feeding to active predation in ancestral vertebrates. However, the origin of neural crest remains controversial, as homologous cell types have not been unambiguously identified in non-vertebrate chordates. Here we show that the tunicate Ciona intestinalis possesses a cephalic melanocyte lineage (a9.49) similar to neural crest that can be reprogrammed into migrating 'ectomesenchyme' by the targeted misexpression of Twist (also known as twist-like 2). Our results suggest that the neural crest melanocyte regulatory network pre-dated the divergence of tunicates and vertebrates. We propose that the co-option of mesenchyme determinants, such as Twist, into the neural plate ectoderm was crucial to the emergence of the vertebrate 'new head'.

著录项

  • 来源
    《Nature》 |2012年第7427期|104-107a2|共5页
  • 作者

    Philip Barron Abitua; Eileen Wagner; Ignacio A. Navarrete; Michael Levine;

  • 作者单位

    Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA;

    Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA;

    Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA;

    Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号