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Too many roads not taken

机译：没有上太多的路

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摘要

When a draft of the human genome was announced in 2000, funders, governments, industry and researchers made grand promises about how genome-based discoveries would revolutionize science. They promised that it would transform our understanding of human biology and disease, and provide new targets for drug discovery. Yet more than 75% of protein research still focuses on the 10% of proteins that were known before the genome was mapped - even though many more have been genetically linked to disease. We performed a bibliometric analysis to assess how research activity has altered over time for three protein families that are central in disease and drug discovery: kinases, ion channels and nuclear receptors. For all three, we found very little change in the pattern of research activity - which proteins are associated with the highest number of publications - over the past 20 years. Even those proteins that have been directly associated with disease remain 'hidden in plain sight', with scientists proving very reluctant to study them.
机译：当2000年宣布人类基因组草图时，资助者，政府，行业和研究人员对基于基因组的发现将如何革新科学做出了巨大的承诺。他们承诺，这将改变我们对人类生物学和疾病的理解，并为药物发现提供新的目标。然而，超过75％的蛋白质研究仍集中在基因组图谱绘制之前已知的10％蛋白质上，尽管有更多的蛋白质与疾病遗传相关。我们进行了文献计量分析，以评估对于疾病和药物发现至关重要的三个蛋白质家族（激酶，离子通道和核受体）的研究活动如何随时间变化。在过去的20年中，我们发现这三者的研究活动模式几乎没有变化-哪些蛋白质与最多的出版物相关。甚至那些与疾病直接相关的蛋白质也被“隐藏在视线之外”，科学家证明非常不愿意研究它们。

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  • 来源
    《Nature》 |2011年第7333期|p.163-165|共3页
  • 作者

    Aled M.Edwards; Ruth Isserlin; Gary D. Bader; Stephen V. Frye; Timothy M. Willson; Frank H. Yu;

  • 作者单位

    University of Toronto, Toronto, Ontario M5G1L7, Canada;

    Donnelly Centre,University of Toronto, Toronto, Ontario M5S 3E1, Canada;

    Donnelly Centre,University of Toronto, Toronto, Ontario M5S 3E1, Canada;

    Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA;

    GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA;

    Program in Neurobiology and Dental Research Institute, School of Dentistry, SeoulNational University, Seoul, 110-749, South Korea;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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