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Local sleep in awake rats

机译：清醒大鼠的局部睡眠

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摘要

In an awake state, neurons in the cerebral cortex fire irregularly and electroencephalogram (EEG) recordings display low-amplitude, high-frequency fluctuations. During sleep, neurons oscillate between 'on' periods, when they fire as in an awake brain, and 'off periods, when they stop firing altogether and the EEG displays high-amplitude slow waves. However, what happens to neuronal firing after a long period of being awake is not known, Here we show that in freely behaving rats after a long period in an awake state, cortical neurons can go briefly 'offline' as in steep, accompanied by slow waves in the local EEG. Neurons often go offline in one cortical area but not in another, and during these periods of 'local steep', the incidence of which increases with the duration of the awake state, rats are active and display an 'awake' EGG. However, they are progressively impaired in a sugar pellet reaching task. Thus, although both the EEG and behaviour indicate wakefulness, local populations of neurons in the cortex may be falling asleep, with negative consequences for performance.
机译：在清醒状态下，大脑皮层中的神经元会不规则地发射，并且脑电图（EEG）记录会显示出低振幅，高频波动。在睡眠期间，神经元会在“清醒”时（就像在清醒的大脑中一样）发射，而在“熄灭时”（当它们完全停止发射而EEG显示出高振幅慢波）之间会振荡。但是，尚不清楚长期处于清醒状态后神经元放电的情况，这里我们表明，在长时间处于清醒状态的自由行为大鼠中，皮质神经元可以像在陡峭状态下短暂地“脱机”，并伴有缓慢的运动。在当地的脑电波。神经元通常在一个皮层区域处于离线状态，而在另一皮层区域则不处于离线状态，并且在这些“局部陡峭”时期（这种状态的发生率随着清醒状态持续时间的增加而增加），大鼠处于活动状态并显示出“清醒”的EGG。但是，它们在糖丸到达任务中逐渐受到损害。因此，尽管脑电图和行为均表示清醒，但是皮质中的局部神经元群体可能正在入睡，这会对性能产生负面影响。

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  • 来源
    《Nature》 |2011年第7344期|p.443-447|共5页
  • 作者

    Vladyslav V. Vyazovskiy; Umberto Olcese; Erin C. Hanlon; Yuval Mr; Chiara Cirelli; Giulio Tononi;

  • 作者单位

    Department of Psychiatry, University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA,PERCRO Laboratory,Scuola Superiore Sant'Anna, 56217,Via Martiri, 11,Pisa, Italy;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard, Wisconsin 53719, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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