Keeping tabs on secretory traffic

C Lord

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Keeping tabs on secretory traffic

机译：密切注意分泌流量

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The secretory pathway transports newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi, packaged in COPII-coated vesicles. Understanding how the directionality of this traffic is achieved is an unanswered question in cell biology. Susan Ferro-Novick and colleagues show that COPII vesicles comprising an inner shell of Sec23p/Sec24p and an outer shell of Secl3p/Sec31p subunits retain their coat until they reach the Golgi. A Golgi-associated kinase, Hrr25p then phosphorylates the Sec23p/Sec24p coat complex. Coat phosphorylation and dephosphorylation are needed for vesicle fusion and budding, respectively. Sec23p interacts in a sequential manner with three binding partners to ensure the directionality of ER-Golgi traffic and prevent the back-fusion of a COPII vesicle with the ER.

机译：分泌途径将新合成的蛋白质从内质网（ER）转运到高尔基体，高尔基体包装在COPII涂层的囊泡中。了解如何实现这种流量的方向性是细胞生物学中尚未解决的问题。 Susan Ferro-Novick及其同事表明，包含Sec23p / Sec24p内壳和Secl3p / Sec31p亚基外壳的COPII囊泡保留其外皮直至到达高尔基体。然后，与高尔基体相关的激酶Hrr25p磷酸化Sec23p / Sec24p外壳复合物。囊泡融合和出芽分别需要涂层磷酸化和去磷酸化。 Sec23p与三个结合配偶体以顺序方式相互作用，以确保ER-高尔基体运输的方向性，并防止COPII囊泡与ER反向融合。

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《Nature》 |2011年第7345期|p.33|共1页
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C Lord;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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Keeping tabs on secretory traffic

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