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A novel protein family mediates Casparian strip formation in the endodermis

机译：一个新的蛋白质家族介导内胚层里帽带的形成

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摘要

Polarized epithelia are fundamental to multicellular life. In animal epithelia, conserved junctional complexes establish membrane diffusion barriers, cellular adherence and sealing of the extracellular space. Plant cellular barriers are of independent evolutionary origin. The root endodermis strongly resembles a polarized epithelium and functions in nutrient uptake and stress resistance. Its defining features are the Casparian strips, belts of specialized cell wall material that generate an extracellular diffusion barrier. The mechanisms localizing Casparian strips are unknown. Here we identify and characterize a family of transmembrane proteins of previously unknown function. These 'CASPs' (Casparian strip membrane domain proteins) specifically mark a membrane domain that predicts the formation of Casparian strips. CASP1 displays numerous features required for a constituent of a plant junctional complex: it forms complexes with other CASPs; it becomes immobile upon localization; and it sediments like a large polymer. CASP double mutants display disorganized Casparian strips, demonstrating a role for CASPs in structuring and localizing this cell wall modification. To our knowledge, CASPs are the first molecular factors that are shown to establish a plasma membrane and extracellular diffusion barrier in plants, and represent a novel way of epithelial barrier formation in eukaryotes.
机译：极化的上皮是多细胞生命的基础。在动物上皮细胞中，保守的连接复合物建立了膜扩散屏障，细胞粘附和细胞外空间的封闭。植物细胞壁垒是独立的进化起源。根部内胚层非常类似于极化的上皮，并在营养吸收和抗逆性中起作用。它的标志性特征是里海带，专门的细胞壁材料带，它们会产生细胞外扩散屏障。定位里海带的机制尚不清楚。在这里，我们确定和表征以前未知功能的跨膜蛋白家族。这些“ CASPs”（里海带状膜结构域蛋白）专门标记了预测里海带状结构形成的膜结构域。 CASP1显示出构成植物交界复合体所需的众多功能：它与其他CASP形成复合体；它在本地化后就无法移动；它像大聚合物一样沉淀。 CASP双重突变体显示出混乱的里海带，证明了CASP在构建和定位这种细胞壁修饰中的作用。据我们所知，CASP是显示出在植物中建立质膜和细胞外扩散屏障的第一个分子因子，并且代表了真核生物上皮屏障形成的新途径。

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  • 来源
    《Nature》 |2011年第7347期|p.380-383|共4页
  • 作者

    Daniele Roppolo; Bert De Rybel; Valerie Denervaud Tendon; Alexandre Pfister; Julien Alassimone; Joop E. M. Vermeer; Misako Yamazaki; York-Dieter Stierhof; Tom Beeckman; Niko Geldner;

  • 作者单位

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

    Wageningen University, Laboratory of Biochemistry, Dreijenlaan 3,6703 HA Wageningen, The Netherlands;

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

    ZMBP, Mikroskopie, Universitaet Tubingen, AufderMorgenstelle 5,72076Tuebingen, Germany;

    Department of Plant Systems Biology, VIB and Department of Plant Biotechnology and Genetics,Ghent University,Technologiepark 927,9052 Ghent, Belgium;

    Department of Plant Molecular Biology, Biophore, UNIL-Sorge, University of Lausanne, 1015 Lausanne, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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