The growing pains of pluripotency

ERIKA CHECK HAYDEN

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The growing pains of pluripotency

机译：多能性的成长之痛

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Five years is an eye-blink in science, but that's all the time it has taken for the concept of adult-cell reprogramming to revolutionize the field of regenerative medicine. In August 2006, Shinya Yamanaka of Kyoto University in Japan told the world that he had turned mouse skin cells into induced pluripo-tent stem (iPS) cells, capable of becoming many types of cell. The following year, he repeated the feat for human cells. Like human embryonic stem cells, iPS cells could potentially be used as therapies, disease models or in drug screening. And iPS cells have clear advantages: they can be made from adult cells, avoiding the contentious need for a human embryo, and they can be derived from people with diseases to create models or even therapies based on a person's genetic make-up.

机译：五年是科学上的转瞬即逝，但这是成年细胞重编程概念彻底革新再生医学领域所花费的时间。 2006年8月，日本京都大学的山中伸弥（Shinya Yamanaka）告诉世界，他已将小鼠皮肤细胞转变为诱导型多能干（iPS）细胞，能够变成多种类型的细胞。次年，他再次为人类细胞壮举。像人类胚胎干细胞一样，iPS细胞可能被用作治疗方法，疾病模型或药物筛选。 iPS细胞具有明显的优势：它们可以由成年细胞制成，从而避免了对人类胚胎的有争议的需求，并且可以从患有疾病的人身上衍生出来，以基于人的基因组成来创建模型甚至疗法。

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《Nature》 |2011年第7347期|p.272-274|共3页
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ERIKA CHECK HAYDEN;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Human First-Trimester Fetal MSC Express Pluripotency Markers and Grow Faster and Have Longer Telomeres Than Adult MSC (vol 25, pg 646, 2007) [J] . Guillot Pascale V., Gotherstrom Cecilia, Chan Jerry, Stem Cells . 2017,第6期

机译：人类孕期胎儿MSC表达多能性标志物，增长速度比成人MSC更快，并具有较长的端粒（Vol 25，PG 646,2007）
2. Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC. [J] . Guillot PV, Gotherstrom C, Chan J, Stem Cells . 2007,第3期

机译：人类早孕胎儿MSC表达多能性标志物，比成年MSC增长更快，端粒更长。
3. An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells [J] . Jamie Trott, Penelope Hayward, Alfonso Martinez Arias, Biology Open . 2014,第7期

机译：细胞外信号与多能性退出动力学之间的相互作用驱动小鼠ES细胞中的细胞命运决定细胞外信号与多能性退出动力学之间的相互作用驱动小鼠ES细胞中的细胞命运决定多能性的退出驱动小鼠ES细胞的细胞命运决定
4. LEarning with academic partners (LEAP) Success and growing pains in the first year [C] . Amber Kemppainen, A J Hamlin, Haylee Diment, IEEE Frontiers in Education Conference . 2017

机译：与学术伙伴的学习（LEAP）第一年的成功和成长中的烦恼
5. Growing Pains: Young Adults' Experiences Living with Inflammatory Bowel Disease [D] . Benn, Beth E. 2019

机译：疼痛加剧：年轻人患有炎性肠病的经历
6. Carbon Offsets: Growing Pains in a Growing Market [O] . Charles W. Schmidt 2009

机译：碳补偿：在不断增长的市场中痛苦加剧
7. Corrigendum: Human First-Trimester Fetal MSC Express Pluripotency Markers and Grow Faster and Have Longer Telomeres Than Adult MSC [O] . 2017

机译：勘误：人类孕期胎儿MSC表达多能性标志物，增长速度比成人MSC更长，并具有较长的端粒

The growing pains of pluripotency

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