COP1 in prostate cancer

A C Vitari

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COP1 in prostate cancer

机译：COP1在前列腺癌中

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Translocations in transcription factors in the E26 transformation-specific (ETS) family are common in prostate cancer. Dixit and colleagues now find that the ubiquitin ligase COP1 normally ubiquitinates certain ETS factors, leading to their degradation. The proteins encoded by the translocations, however, lack the COP1 signal and thus evade the degradation. COP1 acts as a tumour suppressor, and its deletion causes neoplasias in the mouse prostate by increasing ETS factor levels. The authors also show that the loss of COP1,like ETS translocations, can lead to upregulation of ETS factors in human prostate cancers.

机译：E26转化特异性（ETS）家族中转录因子的易位在前列腺癌中很常见。 Dixit及其同事现在发现，泛素连接酶COP1通常使某些ETS因子泛素化，从而导致其降解。但是，由易位编码的蛋白质缺少COP1信号，因此可以避免降解。 COP1起到抑癌作用，其缺失可通过增加ETS因子水平在小鼠前列腺中引起肿瘤形成。作者还表明，像ETS易位一样，COP1的丢失会导致人类前列腺癌中ETS因子的上调。

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《Nature》 |2011年第7347期|p.287|共1页
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A C Vitari;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. A cop1 spa Mutant Deficient in COP1 and SPA Proteins Reveals Partial Co-Action of COP1 and SPA during Arabidopsis Post-Embryonic Development and Photomorphogenesis [J] . Natalia Ordo(n)ez-Herrera, Petra Fackendahl, Xu Yu, 分子植物（英文版） . 2015,第003期

机译：COP1 spa突变体缺乏COP1和SPA蛋白的突变体揭示拟南芥后胚发育和光形态发生过程中COP1和SPA的部分协同作用。
2. The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings [J] . Xu Dongqing, Lin Fang, Jiang Yan, The Plant Cell . 2014,第5期

机译：RING-手指E3泛素连接酶COP1 SUPPRESSOR1负调节暗养拟南芥幼苗中COP1稳态中的COP1丰度。
3. Non-coding and coding genomic variants distinguish prostate cancer, castration-resistant prostate cancer, familial prostate cancer, and metastatic castration-resistant prostate cancer from each other [J] . Alanazi Ibrahim O., Al Shehri Zafer S., Ebrahimie Esmaeil, Molecular Carcinogenesis . 2019,第6期

机译：非编码和编码基因组变体区分前列腺癌，抗阉割前列腺癌，家族性前列腺癌和彼此转移性阉割癌症癌症
4. Discovery of Human Prostate Cancer Biomarkers From a Xenograft Mouse Model and Formalin-fixed, Paraffin-embedded Prostate Cancer Tissue [C] . Hsin-Yao Tang, Lynn Beer, Tony Chang-Wong, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：从异种移植小鼠模型和福尔马林固定，石蜡嵌入前列腺癌组织中发现人前列腺癌生物标志物
5. Replication and Characterization of Snps Associated with Prostate Cancer Survival in Men with Localized Prostate Cancer [D] . Shah, Jainam. 2020

机译：具有局部前列腺癌的男性前列腺癌生存的SNP复制和表征
6. The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings [O] . Dongqing Xu, Fang Lin, Yan Jiang, 2014

机译：RING手指E3泛素连接酶COP1 SUPPRESSOR1负调节暗养拟南芥幼苗中COP1稳态中的COP1丰度。
7. A cop1 spa Mutant Deficient in COP1 and SPA Proteins Reveals Partial Co-Action of COP1 and SPA during Arabidopsis Post-Embryonic Development and Photomorphogenesis [O] . Ordonez-Herrera N., Fackendahl P., Yu X., 2015

机译：COP1 spa突变体缺乏COP1和SPA蛋白的突变体揭示拟南芥胚后发育和光形态发生过程中COP1和SPA的部分协同作用。

COP1 in prostate cancer

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