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Long-term evolution and transmission dynamics of swine influenza A virus

机译：猪甲型流感病毒的长期进化和传播动力学

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摘要

Swine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease and occasionally give rise to human pandemics, including that caused by the H1N1/2009 virus. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic4. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans.
机译：猪A型流感病毒（SwIV）在畜牧业和人类疾病方面造成重大的经济损失，并偶尔引起人类大流行，包括由H1N1 / 2009病毒引起的大流行。猪缺乏系统的和纵向的流感监测，阻碍了重建这种大流行起源的尝试。现有的大多数猪数据来自不同地理区域患病猪的机会性样本，而不是来自特定位置的前瞻性研究，因此对SwIV的进化和传播动态了解甚少。在这里，我们使用来自该地区12年系统监测的650多个SwIV分离株和800多个猪血清的数据集，对香港SwIV的流行病学，遗传和抗原动态进行了定量，并补充了长达34年的数据。洲际病毒的移动导致了重组和谱系的替换，形成了抗原和遗传上多样化的病毒种群，其动力学在数量上与以前观察到的人类流感病毒在动力学上有所不同。我们的发现表明，抗原漂移的增加与重排事件有关，并为猪和人中具有流行潜力的流感病毒的出现提供了见识。

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  • 来源
    《Nature》 |2011年第7348期|p.519-522|共4页
  • 作者

    Dhanasekaran Vijaykrishna; Gavin J. D. Smith; Oliver G. Pybus; Huachen Zhu; Samir Bhatt; Leo L. M. Poon; Steven Riley; Justin Bahl; SiuK. Ma; ChungL. Cheung; RanawakaA. P. M. Perera; Honglin Chen; Kennedy F. Shortridge; Richard J. Webby; Robert G. Webster; Yi Guan; J. S. Malik Peiris;

  • 作者单位

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China,Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Rd, 169857, Singapore;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China,Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Rd, 169857, Singapore;

    Department of Zoology, University of Oxford, South Parks Road, Oxford 0X1 3PS, UK;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China;

    Department of Zoology, University of Oxford, South Parks Road, Oxford 0X1 3PS, UK;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China;

    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China,Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Rd, 169857, Singapore;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China;

    Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital,Memphis, Tennessee 38015, USA;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital,Memphis, Tennessee 38015, USA;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,HKU-Pasteur Research Centre, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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