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Regulate research at the animal-human interface

机译：在动物与人的界面上规范研究

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Chinese scientists have introduced human stem cells into goat fetuses, producing animals with organs that contain functioning human-derived cells1. US scientists have examined the ethics of creating a mouse that has some human-derived brain cells (although they have not done the experiment)2. Many thousands of transgenic rodents, inter-species cell lines and animals grafted with human tissue have been created worldwide, and have helped substantially with the investigation of health and disease and the development and testing of therapies. But few countries have specifically considered the governance of research involving animals that contain human material (ACHM), and the topic has had little public discussion. Potentially controversial science proceeds best in an open environment. Britain has an enviable record of reasonably harmonious research in human embryology owing to parliamentary debate, legislation and regulators who systematically engage the public. However, violent opposition to animal research has sometimes hampered open discussion. We hope that era is behind us, and the opportunity for inclusive discussion of these more subtle issues can be grasped.
机译：中国科学家已将人类干细胞引入山羊胎儿体内，从而生产出动物器官，其器官中含有人类正常运作的细胞1。美国科学家已经研究了创建具有某些人类脑细胞（尽管他们尚未进行实验）的小鼠的伦理学2。在世界范围内已经建立了成千上万种转基因啮齿动物，种间细胞系和移植有人类组织的动物，它们在健康和疾病的研究以及疗法的开发和测试方面提供了极大的帮助。但是，很少有国家专门考虑过涉及包含人类物质（ACHM）的动物的研究的治理，并且该话题几乎没有公开讨论。在开放环境中，可能引起争议的科学进展最好。由于议会辩论，立法和监管机构与公众的系统接触，英国在人类胚胎学方面进行了合理的和谐研究，令人羡慕。但是，对动物研究的猛烈反对有时阻碍了公开讨论。我们希望时代已经过去，可以抓住机会就这些更微妙的问题进行包容性讨论。

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  • 来源
    《Nature》 |2011年第7357期|p.448|共1页
  • 作者

    Martin Bobrow;

  • 作者单位

    University of Cambridge, UK, and chair of the Academy of Medical Sciences working group;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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