Genetic influence on blood pressure

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Genetic influence on blood pressure

机译：遗传对血压的影响

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Compared with other common complex abnormalities, it has proved remarkably difficult to establish the genetic basis of blood-pressure elevation. A multi-stage genome-wide association study involving 200,000 individuals of European descent provides some of the missing detail. The study identified sixteen relevant loci, of which only six contain genes that are known or suspected to regulate blood pressure. An association was found between hypertension, left-ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. Comparison with data from more than 75,000 people of East Asian, South Asian and African ancestries confirmed that many of the variants identified in people with European ancestry also affected blood pressure in other populations.

机译：与其他常见的复杂异常相比，事实证明建立血压升高的遗传基础非常困难。一项涉及200,000个欧洲血统的个体的多阶段全基因组关联研究提供了一些缺少的细节。该研究确定了16个相关基因座，其中只有6个包含已知或怀疑调节血压的基因。高血压，左心室壁厚，中风和冠状动脉疾病之间存在关联，但肾脏疾病或肾功能与疾病无关。与来自东亚，南亚和非洲祖先的75,000多人的数据进行比较，证实在欧洲祖先的人中发现的许多变异也影响了其他人群的血压。

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《Nature》 |2011年第7364期|p.281|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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机译：动脉α_2-NA +泵表达影响血压：新颖的课程，遗传工程化平滑肌特异性A2小鼠
2. Blood Pressure Genetic Risk Score Predicts Blood Pressure Responses to Dietary Sodium and Potassium The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity) [J] . Nierenberg Jovia L., Li Changwei, He Jiang, Hypertension: An Official Journal of the American Heart Association . 2017,第6期

机译：血压遗传风险评分预测膳食钠和钾的血压反应（盐敏感性遗传流行病学网络）
3. Exercise, genetics, and blood pressure: Focus on "Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism" and on "Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women" [J] . Larry A. Sonna, Susan B. Glueck, Xavier Jeunemaitre Physiological genomics . 2002,第0期

机译：运动，遗传学和血压：专注于“关于血管紧张素原M235T多态性的体育锻炼和血压”和“血管紧张素原M235T多态性与绝经后妇女运动血流动力学有关”
4. A wireless and batteryless 130mg 300µW 10b implantable blood-pressure-sensing microsystem for real-time genetically engineered mice monitoring [C] . Peng Cong, Chaimanonart N., Ko W.H., Solid-State Circuits Conference - Digest of Technical Papers, 2009. ISSCC 2009 . 2009

机译：无线和无电池130mg 300µW 10b可植入血压感应微系统，用于实时基因工程小鼠监测
5. A bioecological approach to understanding the interaction of environmental stress and genetic susceptibility in influencing cortisol and blood pressure in African American adults. [D] . Coulon, Sandra Marie. 2014

机译：一种生物生态学方法，用于了解环境压力和遗传易感性对非裔美国人成年人皮质醇和血压的影响。
6. Arterial α2-Na+ pump expression influences blood pressure: lessons from novel genetically engineered smooth muscle-specific α2 mice [O] . Ling Chen, Hong Song, Youhua Wang, -1

机译：动脉α2-Na+泵的表达会影响血压：来自基因改造的新型平滑肌特异性α2小鼠的教训
7. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship [O] . Von Wowern Fredrik, Berglund Garan, Carlson Joyce, 2005

机译：SGK-1的遗传变异与血压，血压随时间的变化以及胰岛素-舒张压的关系有关
8. Exercise, genetics, and blood pressure: Focus on 'Physical Exercise and Blood Pressure With Reference to the Angiotensinogen M285T Polymorphism' and on 'Angiotensinogen M235T Polymorphism Associates With Exercise Hemodynamics in Postmenopausal Women' [R] . Sonna, L. A. , Glueck, S. B. , Jeunemaitre, X. 2002

机译：运动，遗传和血压：关注“参与血管紧张素原m285T多态性的体育锻炼和血压”以及“血管紧张素原m235T多态性与绝经后妇女运动血流动力学的关联”

Genetic influence on blood pressure

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