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Nutrition and the Immune System

机译:营养与免疫系统

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摘要

The immune system is a fascinatingly complex and dynamic system protecting the body against challenges such as pathogens, foreign substances and tissue damage. It must be able to distinguish pathogens from innocuous self or food antigens, to maintain homeostasis and optimal health. The immune response comprises two complementary components: innate and adaptive immunity. At the innate level, the immune response to invading pathogens or toxin is immediate, but non-specific. The complementary adaptive immune system provides a more targeted and specific reaction to pathogens- and antigens for protection which is more robust and long lasting. The 2011 Nobel Prize in Physiology or Medicine was awarded to Bruce Beutler, Jules Hofmann and Ralph Steinman for their pioneering characterization of innate immune cells (dendritic cells), pathways (Toll-like receptor signalling) and mechanisms that instruct adaptive immunity. Their findings acknowledge the integral role of innate immunity in the onset, course and control of adaptive immune responses.
机译:免疫系统是一个令人着迷的复杂而动态的系统,可以保护人体免受诸如病原体,异物和组织损伤之类的挑战。它必须能够将病原体与无害的自身或食物抗原区分开,以维持体内稳态和最佳健康。免疫反应包括两个互补成分:先天免疫和适应性免疫。在先天水平上,对入侵病原体或毒素的免疫反应是即时的,但不是特异性的。互补的适应性免疫系统可对病原体和抗原提供更具针对性和特异性的反应,从而具有更强大,更持久的保护作用。布鲁斯·比特勒(Bruce Beutler),朱尔斯·霍夫曼(Jules Hofmann)和拉尔夫·斯坦曼(Ralph Steinman)因其对先天性免疫细胞(树突状细胞),通路(Toll样受体信号传导)和指示适应性免疫的机制的开创性研究而荣获2011年诺贝尔生理学或医学奖。他们的发现证实了先天免疫在适应性免疫反应的发作,过程和控制中的不可或缺的作用。

著录项

  • 来源
    《Nature》 |2011年第7374期|p.S24-S28|共5页
  • 作者单位

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

    Nestle Research Center, 1000 Lausanne 26, SWITZERLAND;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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