Fixing the barriers

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Fixing the barriers

机译：修复障碍

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Academic researchers and pharmaceutical companies are already investigating therapies that bolster the integrity of epithelia as a treatment for allergies. For example, Irwin McLean and colleagues at University of Dundee, UK, are searching for small molecules that could boost the production of filaggrin and perhaps other components of the skin barrier machinery in eczema patients. They are also investigating drugs that could help epithelial cells'ignore' so-called nonsense mutations to the FLG gene - nonsense mutations are the most common mutations in the filaggrin gene in northern Europeans, and cause the cell's protein synthesis machinery to halt part way through translating the genetic code into the protein.

机译：学术研究人员和制药公司已经在研究可增强上皮完整性的疗法作为过敏性疗法。例如，英国邓迪大学（University of Dundee）的Irwin McLean及其同事正在寻找可促进湿疹患者中丝聚蛋白和皮肤屏障机器其他成分增加的小分子。他们还在研究可以帮助上皮细胞忽略FLG基因所谓的无义突变的药物-无义突变是北欧人丝聚蛋白基因中最常见的突变，会导致细胞的蛋白质合成机制在一定程度上停止将遗传密码翻译成蛋白质。

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《Nature》 |2011年第7374期|p.S13|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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3. Fixing the skin barrier: past, present and future - man and dog compared. [J] . Marsella R. Veterinary Dermatology . 2013,第1期

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4. Fixing the skin barrier: past, present and future - man and dog compared [C] . Rosanna Marsella World Congress of Veterinary Dermatology . 2013

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5. Physiological and growth responses of grassland species to elevated carbon dioxide and increased nitrogen supply with emphasis on symbiotic nitrogen fixers vs. non-fixers. [D] . Lee, Tali Delius. 2001

机译：草地物种对二氧化碳升高和氮供应增加的生理和生长响应，重点是共生固氮剂与非固氮剂。
6. Data on the effects of fertilization on growth rates biomass allocation carbohydrates and nutrients of nitrogen-fixing and non-nitrogen-fixing tree legumes during tropical forest restoration [O] . Roberto K. Jaquetti, José Francisco C. Gonçalves 2021

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7. Proposal for a Council Regulation (EEC) fixing indicative ceilings and establishing Community supervision of imports of certain products originating in Austria (1977); Proposal for a Council Regulation (EEC) fixing indicative ceilings and establishing Community supervision of imports of certain products originating in Finland (1977); Proposal for a Council Regulation (EEC) establishing Community supervision of imports of certain products originating in Iceland (1977); Proposal for a Council Regulation (EEC) fixing indicative ceilings and establishing Community supervision of imports of certain products originating in Norway (1977); Proposal for a Council Regulation (EEC) fixing indicative ceilings and establishing Community supervision of imports of certain products originating in Portugal (1977); Proposal for a Council Regulation (EEC) fixing indicative ceilings and establishing Community supervision of imports of certain products originating in Sweden(1977); Proposal for a Council Regulation (EEC) establishing Community supervision of imports of certain products originating in Switzerland (1977); Draft of decision of the representatives of the governments of the Member States of the European Coal and Steel Community, meeting within the Council establishing supervision of imports of certain products originating in Austria (1977); Draft of decision of the representatives of the governments of the Member States of the European Coal and Steel Community, meeting within the Council establishing supervision of imports of certain products originating in Sweden (1977) (submitted to the Council by the Commission). COM (76) 489 final, 24 September 1976 [O] . 1976

机译：关于理事会条例（EEC）的提案，确定指示性上限并建立共同体对源自奥地利的某些产品进口的监督（1977年）;关于理事会条例（EEC）的提案，确定指示性上限并建立共同体对源自芬兰的某些产品进口的监督（1977年）;建议理事会条例（EEC）建立共同体对源自冰岛的某些产品进口的监督（1977年）;关于理事会条例（EEC）的提案，确定指示性上限并建立共同体对源自挪威的某些产品进口的监督（1977年）;关于理事会条例（EEC）的提案，确定指示性上限并建立共同体对源自葡萄牙的某些产品进口的监督（1977年）;关于理事会条例（EEC）的提案，确定指示性上限并建立共同体对源自瑞典的某些产品进口的监督（1977年）;建议理事会条例（EEC）建立共同体对源自瑞士的某些产品进口的监督（1977年）;欧洲煤钢共同体成员国政府代表的决定草案，在理事会内举行会议，对源自奥地利的某些产品的进口实施监督（1977年）;欧洲煤钢共同体成员国政府代表的决定草案，在理事会内举行会议，对源自瑞典的某些产品的进口实施监督（1977年）（由委员会提交理事会）。 COm（76）489决赛，1976年9月24日

Fixing the barriers

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