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Sacrifice for survival

机译:牺牲生存

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摘要

When oxygen is plentiful, cells convert glucose to energy through the consecutive processes of glycolysis and oxidative respiration. However, cancer cells exhibit what is known as the Warburg effect: even in the presence of oxygen, they prefer the much less efficient process of glucose fermentation for energy production1. This seems counter-intuitive because rapid cell proliferation, which is required for tumour growth, has high energetic demands23.
机译:当氧气充足时,细胞通过糖酵解和氧化呼吸的连续过程将葡萄糖转化为能量。但是,癌细胞表现出所谓的Warburg效应:即使在有氧气存在的情况下,它们也倾向于使用效率低得多的葡萄糖发酵过程来产生能量1。这似乎是违反直觉的,因为肿瘤生长所需的快速细胞增殖具有很高的能量需求23。

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  • 来源
    《Nature》 |2011年第7376期|p.190-191|共2页
  • 作者单位

    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. M.R. is also in the Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB21GA, UK;

    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. M.R. is also in the Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB21GA, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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