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Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila

机译：果蝇中促进攻击的信息素及其受体神经元的鉴定

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摘要

Aggression is regulated by pheromones in many animal species. However, in no system have aggression pheromones, their cognate receptors and corresponding sensory neurons been identified. Here we show that 11-cis-vaccenyl acetate (cVA), a male-specific volatile pheromone, robustly promotes male-male aggression in the vinegar fly Drosophila melanogaster. The aggression-promoting effect of synthetic cVA requires olfactory sensory neurons (OSNs) expressing the receptor Or67d, as well as the receptor itself. Activation of Or67d-expressing OSNs, either by genetic manipulation of their excitability or by exposure to male pheromones in the absence of other classes of OSNs, is sufficient to promote aggression. High densities of male flies can promote aggression by the release of volatile cVA. In turn, cVA-promoted aggression can promote male fly dispersal from a food resource, in a manner dependent on Or67d-expressing OSNs. These data indicate that cVA may mediate negative-feedback control of male population density, through its effect on aggression. Identification of a pheromone-OSN pair controlling aggression in a genetic organism opens the way to unravelling the neurobiology of this evolutionarily conserved behaviour.
机译：攻击受许多动物物种中信息素的调节。但是，在任何系统中都没有识别出攻击性信息素，它们的同源受体和相应的感觉神经元。在这里，我们显示了11-顺式-乙酸乙酸乙烯酯（cVA），一种雄性特有的挥发性信息素，能强烈地促进醋蝇果蝇（Drosophila melanogaster）中的雄性-雄性侵略。合成cVA的攻击促进作用需要表达受体Or67d以及受体本身的嗅觉感觉神经元（OSN）。通过基因操纵其兴奋性或在不存在其他种类的OSN的情况下暴露于雄性信息素，可以激活表达Or67d的OSN，足以促进侵略性。高密度的雄蝇可以通过释放挥发性cVA来促进侵略性。反过来，cVA促进的侵略可以以依赖于表达Or67d的OSN的方式促进从食物资源中释放雄蝇。这些数据表明，cVA可通过其对侵略的影响来介导男性人口密度的负反馈控制。鉴定控制生物体中侵略性的信息素-OSN对为揭示这种进化上保守的行为的神经生物学开辟了道路。

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  • 来源
    《Nature》 |2010年第7278期|227-231|共5页
  • 作者

    Liming Wang; David J. Anderson;

  • 作者单位

    Division of Biology 216-76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

    Division of Biology 216-76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA Howard Hughes Medical institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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