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The endocytic matrix

机译：内吞基质

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摘要

Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its main roles being the resolution of signals in space and time. Many of the functions of endocytosis that are emerging from recent research cannot yet be reconciled with the canonical view of intracellular trafficking but, instead, point to endocytosis being integrated at a deeper level in the cellular 'master plan' (the cellular network of signalling circuits that lie at the base of the cell's make-up). Deconvolution of this level, which we call the 'endocytic matrix', might uncover a fundamental aspect of how a cell is built.
机译：长期以来，内吞作用一直被认为是细胞内化养分和膜相关分子的简单方法。但是，知识的爆炸性增长为我们对这一过程的理解提供了新的维度。现在看来，胞吞作用是信号回路的主要组织者，其主要作用之一是在时空上分辨信号。近期研究中涌现的许多内吞功能尚未与细胞内运输的规范观点相吻合，而是指出内吞作用已在细胞“总体规划”（信号回路的细胞网络）中更深层次地整合这是单元格组成的基础）。对这一水平的反卷积（我们称为“内吞矩阵”）可能会揭示细胞构建方式的基本方面。

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  • 来源
    《Nature》 |2010年第7280期|464-473|共10页
  • 作者

    Giorgio Scita; Pier Paolo Di Fiore;

  • 作者单位

    IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM-IEO Campus, Via Adamello 16,20139, Milan, Italy Department of Medicine, Surgery and Dentistry, Universita degli Studi di Milano, Via A. Di Rudini 8,20122, Milan, Italy;

    IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM-IEO Campus, Via Adamello 16,20139, Milan, Italy Department of Medicine, Surgery and Dentistry, Universita degli Studi di Milano, Via A. Di Rudini 8,20122, Milan, Italy Department of Experimental Oncology, European Institute of Oncology, at the IFOM-IEO Campus, Via Adamello 16.20139, Milan, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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