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Evidence for grid cells in a human memory network

机译：人类存储网络中网格单元的证据

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摘要

Grid cells in the entorhinal cortex of freely moving rats provide a strikingly periodic representation of self-location which is indicative of very specific computational mechanisms. However, the existence of grid cells in humans and their distribution throughout the brain are unknown. Here we show that the preferred firing directions of directionally modulated grid cells in rat entorhinal cortex are aligned with the grids, and that the spatial organization of grid-cell firing is more strongly apparent at faster than slower running speeds. Because the grids are also aligned with each other, we predicted a macroscopic signal visible to functional magnetic resonance imaging (fMRI) in humans. We then looked for this signal as participants explored a virtual reality environment, mimicking the rats' foraging task: fMRI activation and adaptation showing a speed-modulated six-fold rotational symmetry in running direction. The signal was found in a network of entorhinal/subicular, posterior and medial parietal, lateral temporal and medial prefrontal areas. The effect was strongest in right entorhinal cortex, and the coherence of the directional signal across entorhinal cortex correlated with spatial memory performance. Our study illustrates the potential power of combining single-unit electrophysiology with fMRI in systems neuroscience. Our results provide evidence for grid-cell-like representations in humans, and implicate a specific type of neural representation in a network of regions which supports spatial cognition and also autobiographical memory.
机译：自由移动的大鼠的内嗅皮层中的网格细胞提供了惊人的周期性自我定位，这表明非常具体的计算机制。然而，人类中网格细胞的存在及其在整个大脑中的分布是未知的。在这里，我们表明大鼠内嗅皮层中定向调制的网格细胞的首选发射方向与网格对齐，并且网格细胞发射的空间组织比较慢的运行速度更明显。因为网格也彼此对齐，所以我们预测了对人的功能磁共振成像（fMRI）可见的宏观信号。然后，我们在参与者探索虚拟现实环境时模仿了老鼠的觅食任务：fMRI的激活和适应在行驶方向上显示了速度调节的六重旋转对称性，从而寻找了这一信号。该信号在内脏/下丘脑，顶叶后壁和内侧，颞叶外侧和前额内侧区域的网络中发现。该效果在右内嗅皮层中最强，并且跨内嗅皮层的方向性信号的相干性与空间记忆性能相关。我们的研究表明在系统神经科学中将单单元电生理学与功能磁共振成像相结合的潜在能力。我们的结果为人类中网格细胞状表示提供了证据，并暗示了支持空间认知和自传记忆的区域网络中特定类型的神经表示。

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  • 来源
    《Nature》 |2010年第7281期|657-661|共5页
  • 作者

    Christian F. Doeller; Caswell Barry; Neil Burgess;

  • 作者单位

    UCL Institute of Cognitive Neuroscience, London WC1N 3AR, UK UCL Institute of Neurology, London WC1N 3BG, UK;

    UCL Institute of Cognitive Neuroscience, London WC1N 3AR, UK UCL Department of Cell and Developmental Biology, London WC1E 6BT, UK UCL Institute of Behavioural Neuroscience, University College London, London WC1H 0AP, UK;

    UCL Institute of Cognitive Neuroscience, London WC1N 3AR, UK UCL Institute of Neurology, London WC1N 3BG, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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