Lack of inhibition leads to abuse

Arthur C. Riegel; Peter W. Kalivas

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Lack of inhibition leads to abuse

机译：缺乏约束会导致滥用

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Common illnesses such as anxiety disorders, insomnia and even muscle spasms are treated with benzodiazepine drugs, of which diazepam (Valium) is perhaps the best known. But both conventional benzodiazepines and newer benzodiazepine-like compounds (such as zolpidem) are addictive. This limits the therapeutic potential of an otherwise safe class of drugs that has broad clinical applications.rnMost addictive substances activate the same brain circuitry: the dopaminergic system, which is also stimulated by natural rewards, such as food and sex. Benzodiazepines stimulate this circuitry, but the underlying mechanism was unknown, prompting speculation that benzodiazepine addiction involves systems distinct from those involved in dependence on other addictive drugs.rnIn this issue (page 769), Tan et al. report that the missing link connecting benzodiazepines to the dopaminergic circuitry is a select group of GABA_A receptors (γ-aminobutyric acid type A receptors) that reside on neurons known as inhibitory interneurons. These interneu-rons coordinate the output of dopaminergic neurons in the ventral tegmental area (VTA) of the brain.

机译：苯二氮卓类药物可治疗焦虑症，失眠甚至肌肉痉挛等常见疾病，其中地西epa（安定）可能是最著名的药物。但是，传统的苯二氮卓类药物和较新的苯二氮卓类化合物（如唑吡坦）都会令人上瘾。这限制了具有其他临床应用的安全性类别的药物的治疗潜力。大多数成瘾性物质激活相同的大脑回路：多巴胺能系统，其也受到食物和性等自然奖励的刺激。苯二氮卓类药物会刺激这一电路，但其潜在机制尚不清楚，这促使人们推测苯二氮卓类药物成瘾涉及的系统与依赖其他成瘾性药物的系统不同。在这个问题上（第769页），Tan等人。报告指出，将苯并二氮杂卓连接至多巴胺能回路的缺失环节是驻留在神经元中的一组GABA_A受体（γ-氨基丁酸A型受体），该神经元被称为抑制性中间神经元。这些神经元协调大脑腹侧被盖区（VTA）中多巴胺能神经元的输出。

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来源
《Nature》 |2010年第7282期|743-744|共2页
作者
Arthur C. Riegel; Peter W. Kalivas;
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作者单位

Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA;

Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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6. Lack of inhibition leads to abuse [O] . Arthur C. Riegel, Peter W. Kalivas -1

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Lack of inhibition leads to abuse

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