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首页> 外文期刊>Nature >Changes in Hox genes' structure and function during the evolution of the squamate body plan
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Changes in Hox genes' structure and function during the evolution of the squamate body plan

机译：鳞状上皮计划演变过程中Hox基因的结构和功能的变化

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摘要

Hox genes are central to the specification of structures along the anterior-posterior body axis, and modifications in their expression have paralleled the emergence of diversity in vertebrate body plans. Here we describe the genomic organization of Hox clusters in different reptiles and show that squamates have accumulated unusually large numbers of transposable elements at these loci, reflecting extensive genomic rearrangements of coding and non-coding regulatory regions. Comparative expression analyses between two species showing different axial skeletons, the corn snake and the whiptail lizard, revealed major alterations in Hox13 and Hox10 expression features during snake somitogenesis, in line with the expansion of both caudal and thoracic regions. Variations in both protein sequences and regulatory modalities of posterior Hox genes suggest how this genetic system has dealt with its intrinsic collinear constraint to accompany the substantial morphological radiation observed in this group.
机译：Hox基因是沿前后身体轴结构规范的中心，其表达修饰与脊椎动物身体计划中多样性的出现平行。在这里，我们描述了不同爬行动物中Hox簇的基因组组织，并表明鳞状细胞在这些基因座上积累了异常大量的转座因子，反映了编码和非编码调控区的广泛基因组重排。两种显示不同轴向骨骼的物种（玉米蛇和鞭尾蜥蜴）之间的比较表达分析表明，蛇的体形成过程中Hox13和Hox10表达特征发生了重大变化，与尾部和胸部区域的扩张一致。后Hox基因的蛋白质序列和调控方式的变化表明，该遗传系统如何处理其固有的共线约束，以伴随在该组中观察到的大量形态辐射。

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  • 来源
    《Nature》 |2010年第7285期|99-103|共5页
  • 作者

    Nicolas Di-Poie; Juan I. Montoya-Burgos; Hilary Miller; Olivier Pourquie; Michel C. Milinkovitch; Denis Duboule;

  • 作者单位

    National Research Center 'Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;

    National Research Center 'Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;

    School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand;

    Howard Hughes Medical Institute, Kansas City, Missouri 64110, USA Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA Institute de Genetique et de Biologie Molecu'aire et Cellulaire, CNRS (UMR 7104), Inserm U964, Universite de Strasbourg, Illkirch, F-67400, France;

    National Research Center 'Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland;

    National Research Center 'Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland School of Life Sciences, Federal Institute of Technology CEPFL), 1015 Lausanne, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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