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首页> 外文期刊>Nature >Start/stop signals emerge in nigrostriatal circuits during sequence learning
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Start/stop signals emerge in nigrostriatal circuits during sequence learning

机译：序列学习过程中黑纹状体回路中出现启动/停止信号

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摘要

Learning new action sequences subserves a plethora of different abilities such as escaping a predator, playing the piano, or producing fluent speech. Proper initiation and termination of each action sequence is critical for the organization of behaviour, and is compromised in nigrostriatal disorders like Parkinson's and Huntington's diseases. Using a self-paced operant task in which mice learn to perform a particular sequence of actions to obtain an outcome, we found neural activity in nigrostriatal circuits specifically signalling the initiation or the termination of each action sequence. This start/stop activity emerged during sequence learning, was specific for particular actions, and did not reflect interval timing, movement speed or action value. Furthermore, genetically altering the function of striatal circuits disrupted the development of start/stop activity and selectively impaired sequence learning. These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders.
机译：学习新的动作序列可以发挥许多不同的功能，例如逃避掠食者，弹钢琴或发出流畅的语音。每个动作序列的正确启动和终止对于行为的组织至关重要，并且在诸如帕金森氏病和亨廷顿氏病的黑纹状体疾病中受到损害。使用一种自定进度的操作任务，在该任务中，小鼠学会执行特定的动作序列以获得结果，我们在黑纹状体电路中发现了神经活动，具体表明了每个动作序列的开始或终止。这种开始/停止活动是在顺序学习过程中出现的，是针对特定动作的，并不反映间隔时间，运动速度或动作值。此外，遗传改变纹状体回路的功能破坏了开始/停止活性的发展，并选择性地损害了序列学习。这些结果对于理解动作的功能组织以及在基底神经节疾病中观察到的序列起始和终止损伤具有重要意义。

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  • 来源
    《Nature》 |2010年第7305期|P.457-462|共6页
  • 作者

    Xin Jin; Rui M. Costa;

  • 作者单位

    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA;

    rnLaboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9412, USA Champalimaud Neuroscience Programme at Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, Oeiras 2780-156, Portugal;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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