首页> 外文期刊>Nature >Amygdalar and hippocampal substrates of anxious temperament differ in their heritability
【24h】

Amygdalar and hippocampal substrates of anxious temperament differ in their heritability

机译:气质的杏仁核和海马底物的遗传力不同

获取原文
获取原文并翻译 | 示例
           

摘要

Anxious temperament (AT) in human and non-human primates is a trait-like phenotype evident early in life that is characterized by increased behavioural and physiological reactivity to mildly threatening stimuli. Studies in children demonstrate that AT is an important risk factor for the later development of anxiety disorders, depression and comorbid substance abuse5. Despite its importance as an early predictor of psychopathology, little is known about the factors that predispose vulnerable children to develop AT and the brain systems that underlie its expression. To characterize the neural circuitry associated with AT and the extent to which the function of this circuit is heritable, we studied a large sample of rhesus monkeys phenotyped for AT. Using 238 young monkeys from a multigenerational single-family pedigree, we simultaneously assessed brain metabolic activity and AT while monkeys were exposed to the relevant ethological condition that elicits the phenotype. High-resolution ~(18)F-labelled deoxyglucose positron-emission tomography (FDG-PET) was selected as the imaging modality because it provides semi-quantitative indices of absolute glucose metabolic rate, allows for simultaneous measurement of behaviour and brain activity, and has a time course suited for assessing temperament-associated sustained brain responses. Here we demonstrate that the central nucleus region of the amygdala and the anterior hippocampus are key components of the neural circuit predictive of AT. We also show significant heritability of the AT phenotype by using quantitative genetic analysis. Additionally, using voxelwise analyses, we reveal significant heritability of metabolic activity in AT-associated hippocampal regions. However, activity in the amygdala region predictive of AT is not significantly heritable. Furthermore, the heritabilities of the hippocampal and amygdala regions significantly differ from each other. Even though these structures are closely linked, the results suggest differential influences of genes and environment on how these brain regions mediate AT and the ongoing risk of developing anxiety and depression.
机译:人类和非人类灵长类动物的气质(AT)是生命早期出现的一种性状样表型,其特征是对轻度刺激的行为和生理反应性增加。在儿童中进行的研究表明,AT是焦虑症,抑郁症和共病药物滥用后期发展的重要危险因素5。尽管它作为心理病理学的早期预测者很重要,但对于易患弱势儿童易患AT的因素及其表达的脑系统知之甚少。为了表征与AT相关的神经回路以及该回路的功能可遗传的程度,我们研究了为AT表型化的恒河猴的大量样本。我们使用来自多代单亲谱系的238只幼猴,同时评估了猴子暴露于引发表型的相关伦理学条件下的脑代谢活性和AT。选择高分辨率〜(18)F标记的脱氧葡萄糖正电子发射断层扫描(FDG-PET)作为成像方式,因为它提供了绝对葡萄糖代谢率的半定量指标,可以同时测量行为和大脑活动,并且有一个适合评估与气质相关的持续性大脑反应的时间课程。在这里,我们证明杏仁核和前海马体的中央核区是AT的神经回路预测的关键组成部分。通过使用定量遗传分析,我们还显示了AT表型的显着遗传力。此外,使用体素分析,我们揭示了AT相关海马区代谢活动的显着遗传性。但是,杏仁核区域中预测AT的活性并不显着。此外,海马区和杏仁核区的遗传力彼此显着不同。即使这些结构紧密相连,结果也表明基因和环境对这些大脑区域如何介导AT以及持续发展的焦虑和抑郁风险的影响不同。

著录项

  • 来源
    《Nature》 |2010年第7308期|P.864-868ⅲ|共6页
  • 作者单位

    Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA;

    rnDepartment of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA;

    rnDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA;

    rnBaylor College of Medicine, Houston, Texas 77030, USA Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA;

    Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA;

    rnSouthwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA;

    Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA;

    rnSouthwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA;

    Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号