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Altruistic defence

机译:利他防御

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摘要

A charitable deed by a few cells in a bacterial culture can help the rest of that population survive in the presence of antibiotics. This finding can aid further research into a major problem in public health.rnBacterial resistance to an antibiotic arises when mutations in the DNA of a few cells in a bacterial population enable them to fend off the harmful effects of the antibiotic. This gives such cells a selective growth advantage through, for example, being able to pump out the antibiotic faster than it can kill them. The mutant bacteria pass on the advantage to their daughter cells and to subsequent generations. Through such amplification, they can outgrow their non-resistant neighbours and eventually come to dominate the population, making an antibiotic generally ineffective. This, then, is the cause of the global challenge of widespread resistance to antibiotics.
机译:由细菌培养物中的几个细胞组成的慈善行为可以帮助其余人口在存在抗生素的情况下生存。这一发现可以帮助进一步研究公共卫生中的一个主要问题。当细菌种群中一些细胞的DNA突变使它们能够抵御抗生素的有害作用时,就会产生对抗生素的细菌耐药性。通过例如能够以比杀死它们更快的速度泵出抗生素,从而赋予此类细胞选择性的生长优势。突变细菌将其优势传给了它们的子代细胞和后代。通过这种扩增,他们可以使自己的非耐药性邻居超过其自身,并最终在人群中占主导地位,从而使抗生素普遍无效。因此,这是对抗生素广泛耐药的全球挑战的原因。

著录项

  • 来源
    《Nature》 |2010年第7311期|P.34-35|共2页
  • 作者单位

    Departments of Physics and of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

    rnDepartments of Physics and of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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