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Functional connectivity in the retina at the resolution of photoreceptors

机译:视网膜在感光器分辨率下的功能连接

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摘要

To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications of these for colour vision. Multi-electrode technology was used to record simultaneously from complete populations of the retinal ganglion cell types (midget, parasol and small bistratified) that transmit high-resolution visual signals to the brain. Fine-grained visual stimulation was used to identify the location, type and strength of the functional input of each cone photoreceptor to each ganglion cell. The populations of ON and OFF midget and parasol cells each sampled the complete population of long- and middle-wavelength-sensitive cones. However, only OFF midget cells frequently received strong input from short -wavelength-sensitive cones. ON and OFF midget cells showed a small non-random tendency to selectively sample from either long- or middle-wavelength-sensitive cones to a degree not explained by clumping in the cone mosaic. These measurements reveal computations in a neural circuit at the elementary resolution of individual neurons.
机译:要了解神经回路,需要了解其连通性。在这里,我们报告了在单细胞分辨率下猕猴视网膜的输入层和输出层之间的功能连通性的测量结果,以及这些测量结果对彩色视觉的影响。多电极技术用于同时记录视网膜神经节细胞类型(侏儒,阳伞和小二层小细胞)的完整种群,这些种群将高分辨率的视觉信号传输到大脑。细粒度的视觉刺激被用来识别每个锥体感光器向每个神经节细胞的功能输入的位置,类型和强度。 ON和OFF小型和遮阳伞细胞群体均采样了长波长和中波长敏感锥的完整群体。但是,只有OFF小型单元格经常收到来自短波长敏感圆锥体的强输入。 ON和OFF侏儒细胞显示出小的非随机趋势,可以选择性地从长波长或中波长敏感锥中进行采样,其程度无法通过锥状镶嵌结块来解释。这些测量揭示了在单个神经元基本分辨率的神经回路中的计算。

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  • 来源
    《Nature》 |2010年第7316期|P.673-677ⅲ|共6页
  • 作者单位

    Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA;

    rnSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA;

    rnSanta Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064, USA;

    rnSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA;

    rnSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA Department of Statistics and Center for Theoretical Neuroscience, Columbia University, New York, New York 10027, USA;

    rnSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA;

    rnSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA;

    rnDepartment of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, UK;

    rnDepartment of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, UK;

    rnFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, 23 30-059 Krakow, Poland;

    rnDepartment of Statistics and Center for Theoretical Neuroscience, Columbia University, New York, New York 10027, USA;

    rnSanta Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064, USA;

    rnSystems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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