Perforin and pore formation

首页> 外文期刊>Nature >Perforin and pore formation

【24h】

Perforin and pore formation

机译：穿孔素和孔形成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The pore-forming immunity protein perforin, essential for the elimination of virally infected and cancerous cells, is released by natural killer and cytotoxic T cells. The structure of a perforin monomer, mouse perforin R213E, has been determined. Analysis of the structure and a cryo-electron microscopy reconstruction suggests that perforin monomers adopt an 'inside-out' orientation in the pore, which may explain how perforin delivers pro-apoptotic proteases into target cells.

机译：形成孔的免疫蛋白穿孔素对消除病毒感染和癌细胞至关重要，它是由自然杀伤和细胞毒性T细胞释放的。已经确定了穿孔素单体（小鼠穿孔素R213E）的结构。结构分析和冷冻电子显微镜重建表明，穿孔素单体在孔中采用“由内而外”的取向，这可以解释穿孔素如何将促凋亡蛋白酶传递到靶细胞中。

著录项

来源
《Nature》 |2010年第7320期|p.39|共1页
作者

展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin [J] . Natalya Lukoyanova, Stephanie C. Kondos, Irene Farabella, PLoS Biology . 2015,第2期

机译：穿孔素相关蛋白质胸抑素蛋白孔隙形成过程中的构象变化
2. In silico analysis of calcium binding pocket of perforin like protein 1: insights into the regulation of pore formation [J] . Swati Garg, Vijeta Sharma, Dandugudumula Ramu, Systems and Synthetic Biology . 2015,第Suppla1期

机译：在计算机模拟中分析穿孔素样蛋白的钙结合口袋1：洞察孔形成的调节
3. Packing a punch: The mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins [J] . Dunstone M.A., Tweten R.K. Current Opinion in Structural Biology . 2012,第3期

机译：包装冲头：胆固醇依赖性胞嘧啶和膜攻击复合物/穿孔蛋白蛋白质的孔形成机制
4. Role of Perforin and Granzyme B of Cytotoxic T Lymphocyte in the Onset of Peptic Ulcer Formation [C] . Tadashi Ohara, Tetsuo Morishita, Hidekazu Suzuki, Keio International Symposia for Life Sciences and Medicine . 2005

机译：细胞毒性T淋巴细胞对白细胞毒性T淋巴细胞在消化性溃疡形成发作中的作用
5. A Conserved Cholesterol-Dependent Cytolysin Motif Directs Prepore and Pore Formation and Reveals a New Class of Pore-Forming Proteins [D] . Evans, Jordan Craig. 2020

机译：保守的胆固醇依赖性胞嘧啶基序指示觅食和孔形成，揭示了一种新的孔形成蛋白
6. Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin [O] . Natalya Lukoyanova, Stephanie C. Kondos, Irene Farabella, 2015

机译：穿孔素相关蛋白Pleurotolysin在孔形成过程中的构象变化
7. Conformational changes during pore formation by the perforin-related protein pleurotolysin [O] . Lukoyanova Natalya, Kondos S.C., Farabella Irene, 2015

机译：穿孔素相关蛋白胸膜溶血素在孔形成过程中的构象变化
8. Core Scale and Pore Scale Studies of Carbon Dioxide Migration in Saline Formations [R] . Benson, S. M. 2006

机译：盐渍土中二氧化碳迁移的核心尺度和孔隙尺度研究

Perforin and pore formation

摘要

著录项

相似文献

相关主题

期刊订阅