Metabolic link to breast cancer

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Metabolic link to breast cancer

机译：代谢与乳腺癌的联系

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A protein that senses a cell's metabolic state may serve as a 'switch' to allow breast cancer to develop. This could be a molecular reason for why a high intake of calories and weight gain are strong risk factors for breast cancer. Kevin Gardner of the National Cancer Institute in Bethesda, Maryland, and his colleagues looked at the protein CtBP, which acts as a metabolic sensor. The protein is activated when it binds to NADH, an important indicator of a cell's metabolic activity.

机译：感知细胞代谢状态的蛋白质可能充当“开关”，使乳腺癌得以发展。这可能是为什么摄入大量卡路里和体重增加是乳腺癌的重要危险因素的分子原因。马里兰州贝塞斯达市国家癌症研究所的凯文·加德纳（Kevin Gardner）和他的同事研究了CtBP蛋白，它可以作为代谢传感器。蛋白质与NADH结合时会被激活，NADH是细胞代谢活性的重要指标。

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《Nature》 |2010年第7323期|p.478|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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2. Breast cancer and metabolic syndrome linked through the plasminogen activator inhibitor-1 cycle. [J] . Beaulieu LM, Whitley BR, Wiesner TF, BioEssays : . 2007,第10期

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3. Cumulative Incidence of Non-breast Cancer Mortality and Breast Cancer Risk by Comorbidity and Age among Older Women Undergoing Screening Mammography: The Medicare-linked Breast Cancer Surveillance Consortium Cohort Study [J] . Demb J., Abraham L., Miglioretti D. L., Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2018,第3期

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4. MODELLING CANCER LIPOGENESIS USING LA-REIMS METABOLIC FLUX ANALYSIS IN BREAST CANCER CELL LINES [C] . Seyma Turkseven, Nikolaos Koundouros, Renata Soares, International Mass Spectrometry Conference . 2018

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5. All-Cause and Cause-Specific Mortality among Medicaid-Insured Women with Preexisting Type 2 Diabetes Mellitus Diagnosed with Breast Cancer: An Epidemiological Analysis of Linked New York State Medicaid and Cancer Registry Data [D] . Lawrence, Wayne R. 2020

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6. Associations of Metabolic syndrome and C-reactive protein with Mortality from total cancer obesity-linked cancers and Breast Cancer among Women in NHANES III [O] . Wambui G. Gathirua-Mwangi, Yiqing Song, Patrick Monahan, -1

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7. Associations of metabolic syndrome and C-reactive protein with mortality from total cancer, obesity-linked cancers and breast cancer among women in NHANES III [O] . Wambui G. Gathirua-Mwangi, Yiqing Song, Patrick O. Monahan, 2018

机译：代谢综合征和C反应蛋白与癌症中患有总癌症，肥胖关联癌症和乳腺癌的死亡的关联

Metabolic link to breast cancer

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