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Making Connections

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摘要

At first glance, Jeff Lichtman seems to be hanging long strips of sticky tape from the walls of his Harvard lab. The tape flutters in the breeze from the air-conditioner. But closer inspection reveals that this is not tape: it is the brain of a mouse, rendered into one long, delicate strip of tissue and fixed onto a plastic film. When the film is tilted to the light, the tissue becomes visible, like the smear of a greasy fingerprint. These smudges are the creation of a new brain-slicing machine invented by Lichtman, a molecular and cellular biologist at Harvard University, along with Kenneth Hayworth, a graduate student at the University of Southern California, Los Angeles. Called the automatic tape-collecting lathe ultramicrotome (ATLUM), the machine resembles an old-fashioned film projector with two large reels. At its centre is a fixed diamond blade that cuts continuously into a rotating mouse brain, much like an apple parer.
机译:乍看之下,杰夫·利希特曼(Jeff Lichtman)似乎在哈佛实验室的墙上悬挂着长条胶带。胶带从空调的微风中飘动。但是仔细检查发现这不是胶带:它是老鼠的大脑,被剥成一条细长的细条组织,固定在塑料膜上。当胶片倾斜于光线时,组织变得可见,就像油腻的指纹涂片一样。这些污迹是由哈佛大学分子与细胞生物学家利希特曼(Lichtman)和南加州大学洛杉矶分校的研究生肯尼斯·海沃思(Kenneth Hayworth)发明的,这是一种新型的大脑切片机的创造。该机器称为自动收带车床超薄切片机(ATLUM),类似于带有两个大卷轴的老式电影放映机。它的中心是固定的钻石刀片,该刀片连续地切入旋转的老鼠的大脑,就像苹果削皮器一样。

著录项

  • 来源
    《Nature》 |2009年第7229期|p.524-527|共4页
  • 作者

    Jonah Lehrer;

  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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