The Snail That Turned

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The Snail That Turned

机译：变成蜗牛

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The chirality (direction of coiling) of snail shells is an enduring biological puzzle. Cris-tina Grande and Nipam Patel now show that snail chirality is regulated by nodal, a gene well known for its role in vertebrate left-right asymmetry. Most animals are bilaterally symmetrical, but within that framework display varying amounts of left-right asymmetry. In vertebrates and other deuterostomes, the molecular pathway that leads to asymmetry utilizes the signalling molecule Nodal. Grande and Patel found the evolutionary equivalents of Nodal and one of its targets, Pitx, in two snail species, and show that loss of nodal disrupts shell coiling. This shows that the nodal signalling pathway is primitive for all bilaterians, and is not a particular feature of deuterostomes, as had been suspected.

机译：蜗牛壳的手性（卷曲方向）是一个持久的生物难题。克里斯蒂娜·格兰德（Cris-tina Grande）和尼帕·帕特尔（Nipam Patel）现在表明，蜗牛的手性受节点调控，该基因以其在脊椎动物左右不对称中的作用而闻名。大多数动物是左右对称的，但在该框架内显示出不同程度的左右不对称。在脊椎动物和其他氘化子宫口中，导致不对称的分子途径利用信号分子Nodal。 Grande和Patel在两个蜗牛物种中发现了Nodal及其靶标之一Pitx的进化等价物，并表明nodal的缺失破坏了壳的卷曲。这表明，节点信号通路对所有双语者都是原始的，并非氘核口罩的特殊特征，正如人们所怀疑的那样。

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《Nature》 |2009年第7232期|931|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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机译：Alien蜗牛，黑色鳞片，Tegise蜗牛，Stenomelania Boninensis，在Ogasawara（Bonin）群岛中，特别参考流银行建设对Thiarid蜗牛的影响

The Snail That Turned

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